华中医学杂志
華中醫學雜誌
화중의학잡지
CENTRAL CHINA MEDICAL JOURNAL
2001年
1期
32-33
,共2页
李良波%谢芬%谢宝珊%夏瑞%赵端仪
李良波%謝芬%謝寶珊%夏瑞%趙耑儀
리량파%사분%사보산%하서%조단의
组织氧分压%肠管生机%缺血再灌注%氧分压传感针
組織氧分壓%腸管生機%缺血再灌註%氧分壓傳感針
조직양분압%장관생궤%결혈재관주%양분압전감침
目的 探讨大白兔组织氧分压与缺血再灌注肠管生机的关系。方法 将20只大白兔随机分成A、B、C、D四组，缺血时间分别为1、2、3、4小时，再灌注时间均为24小时，应用二通道组织氧测定仪及氧分压传感针测定缺血前、缺血及再灌注过程中的肠肌层氧分压值，24小时灌注时间到达后立即取该段肠管作组织病理学检查，并分析氧分压与病理组织结果的相关性。结果 正常情况下组织氧分压为(8.4±1.6)kPa。A、B、C、D四组缺血末的氧分压分别为(4.1±1.5)kPa、(2.9±0.6)kPa、(1.9±0.7)kPa、(0.9±0.2)kPa，再灌注24小时氧分压分别为(6.9±0.9)kPa、(6.2±1.1)kPa、(3.1±0.7)kPa、(2.8±0.4)kPa。病理结果显示A、B两组损伤轻，C、D两组损伤严重，A、B两组与C、D两组差异显著。病理结果与缺血末、再灌注30分钟、再灌注24小时的氧分压的相关系数分别为-0.63(P＜0.01)、-0.70(P＜0.01)、-0.89(P＜0.01)。结论 组织氧分压测定可用于缺血再灌注肠管生机的评估。
目的 探討大白兔組織氧分壓與缺血再灌註腸管生機的關繫。方法 將20隻大白兔隨機分成A、B、C、D四組，缺血時間分彆為1、2、3、4小時，再灌註時間均為24小時，應用二通道組織氧測定儀及氧分壓傳感針測定缺血前、缺血及再灌註過程中的腸肌層氧分壓值，24小時灌註時間到達後立即取該段腸管作組織病理學檢查，併分析氧分壓與病理組織結果的相關性。結果 正常情況下組織氧分壓為(8.4±1.6)kPa。A、B、C、D四組缺血末的氧分壓分彆為(4.1±1.5)kPa、(2.9±0.6)kPa、(1.9±0.7)kPa、(0.9±0.2)kPa，再灌註24小時氧分壓分彆為(6.9±0.9)kPa、(6.2±1.1)kPa、(3.1±0.7)kPa、(2.8±0.4)kPa。病理結果顯示A、B兩組損傷輕，C、D兩組損傷嚴重，A、B兩組與C、D兩組差異顯著。病理結果與缺血末、再灌註30分鐘、再灌註24小時的氧分壓的相關繫數分彆為-0.63(P＜0.01)、-0.70(P＜0.01)、-0.89(P＜0.01)。結論 組織氧分壓測定可用于缺血再灌註腸管生機的評估。
목적 탐토대백토조직양분압여결혈재관주장관생궤적관계。방법 장20지대백토수궤분성A、B、C、D사조，결혈시간분별위1、2、3、4소시，재관주시간균위24소시，응용이통도조직양측정의급양분압전감침측정결혈전、결혈급재관주과정중적장기층양분압치，24소시관주시간도체후립즉취해단장관작조직병이학검사，병분석양분압여병리조직결과적상관성。결과 정상정황하조직양분압위(8.4±1.6)kPa。A、B、C、D사조결혈말적양분압분별위(4.1±1.5)kPa、(2.9±0.6)kPa、(1.9±0.7)kPa、(0.9±0.2)kPa，재관주24소시양분압분별위(6.9±0.9)kPa、(6.2±1.1)kPa、(3.1±0.7)kPa、(2.8±0.4)kPa。병리결과현시A、B량조손상경，C、D량조손상엄중，A、B량조여C、D량조차이현저。병리결과여결혈말、재관주30분종、재관주24소시적양분압적상관계수분별위-0.63(P＜0.01)、-0.70(P＜0.01)、-0.89(P＜0.01)。결론 조직양분압측정가용우결혈재관주장관생궤적평고。
Objective To evaluate the ability of tissue oxygen tension todetermine the intestinal viability. Methods Twenty albino rabbits were divided into four groups randomly.An isolated ischemic bowel loop was made in each rabbit and the clamping and rubber bands were released at intervals of 1,2,3 and 4 h in different groups. Tissue oxygen tensions were measured before ischemia and during ischemia/reperfusion by using PO2 sensor needle. The histopathological examination of the involved intestines were made 24 hours after reperfusion. The correlation between PO2 and the pathological features was analyzed. Results The tissue oxygen tension was (8.4±1.6) kPa before ischemia.PiO2 in the four groups was (4.1±1.5) kPa, (2.9±0.6) kPa, (1.9±0.7) kPa, (0.9±0.2) kPa in the end of the ischemia respectively. PiO2 in the four groups was (6.9±0.9) kPa, (6.2±1.1) kPa, (3.1±0.7) kPa and (2.8±0.4) kPa 24 h after reperfusion respectively. The pathogical examination revealed that the lesion was mild in the groups A and B, while the lesion was severe in the groups C and D, indicating a negative correlation between the pathological degree and PiO2 (r=-0.63, -0.70， -0.89 respectively, all P＜0.01).Conclusion Measurement of the tissue oxygen tension may be a useful method to assess the intestinal viability.
