生命科学研究
生命科學研究
생명과학연구
LIFE SCIENCE RESEARCH
2002年
1期
20-30
,共11页
衰老%基因%Hayflick极限%氧化应激%糖基化
衰老%基因%Hayflick極限%氧化應激%糖基化
쇠로%기인%Hayflick겁한%양화응격%당기화
aging%genes%Hayflick limit%oxidative stress%glyca tion
综述20世纪与基因相关的衰老原理的探索及其进展.整体动物水平的衰老研究归纳了衰老的诸多表象但疏于对衰老本质的探讨.线粒体-自由基衰老学说阐述了线粒体DNA的损伤与衰老有很大的相关性.由Hayflick分裂限制衍生的端粒衰老学说给衰老机制提供了重要信息.目前狭隘的基因程序化衰老学说已和损伤衰老概念有机的联系在了一起.总之,自由基衰老学说得到了氧化衰老学说和糖基化衰老学说的补充逐渐形成了生化副反应与基因衰老学说的大统一衰老机制板块理论.
綜述20世紀與基因相關的衰老原理的探索及其進展.整體動物水平的衰老研究歸納瞭衰老的諸多錶象但疏于對衰老本質的探討.線粒體-自由基衰老學說闡述瞭線粒體DNA的損傷與衰老有很大的相關性.由Hayflick分裂限製衍生的耑粒衰老學說給衰老機製提供瞭重要信息.目前狹隘的基因程序化衰老學說已和損傷衰老概唸有機的聯繫在瞭一起.總之,自由基衰老學說得到瞭氧化衰老學說和糖基化衰老學說的補充逐漸形成瞭生化副反應與基因衰老學說的大統一衰老機製闆塊理論.
종술20세기여기인상관적쇠로원리적탐색급기진전.정체동물수평적쇠로연구귀납료쇠로적제다표상단소우대쇠로본질적탐토.선립체-자유기쇠노학설천술료선립체DNA적손상여쇠로유흔대적상관성.유Hayflick분렬한제연생적단립쇠노학설급쇠로궤제제공료중요신식.목전협애적기인정서화쇠노학설이화손상쇠로개념유궤적련계재료일기.총지,자유기쇠노학설득도료양화쇠노학설화당기화쇠노학설적보충축점형성료생화부반응여기인쇠노학설적대통일쇠로궤제판괴이론.
Several up to date most important theories on aging m echanisms and gen erelated aging studies that were developed during the 20's century were review e d. The theories of aging at the whole animal level reveal important aging manife stations, but most of them lacking accurate explanations of the aging mechanisms . The mitochondriafree radical theory of aging based mainly on free radical th e ory of aging was closely gene related. The Hayflick Limit, the telomere theory o f aging and DNA damage during stresses all provide specific knowledge about the cellular aging processes. Narrowminded search for longevitygenes has been un su ccessful, ending up with a conjunction of programmed aging with stochastic aging concepts. The free radical theory of aging is supplemented by the oxidative str ess theory of aging and the glycation/Maillard reaction theory of aging for cove ring a full scale of biological deteriorative side reactions.
