CAJ | 학술논문

目的　探讨血脂水平与冠心病发病的关系. 方法　选择住院确诊的冠心病患者84例为病例组，排除冠心病的住院患者或健康体检者163例为对照组，对两组的血脂水平、脂蛋白（a）的均数进行比较，并用单因素和多因素分析计算危险因素的优势比（OR）及OR95%可信限（95%CI）. 结果　病例组的总胆固醇、三酰甘油、高密度脂蛋白水平分别为4.13，1.79和1.16 mmolAL-1，脂蛋白（a）为0.38 g.L-1，而对照组血脂三项为3.82，1.44和1.34 mmolAL-1，脂蛋白（a）为0.16 gAL-1，两组间均有显著的统计学差异（P<0.05）; 单因素分析显示: 上述4项指标的OR值分别为3.03， 2.42，3.76 和0.21. 多因素分析结果显示: 被筛选进入Logistic回归方程的变量分别为高密度脂蛋白、脂蛋白（a）、胆固醇水平和每日吸烟量. 结论　吸烟和脂代谢紊乱是我国冠心病患者的主要危险因素，我国的胆固醇水平以国际统一标准作为正常值界限，标准过高. 这些线索将为我国冠心病危险因素的深入研究和冠心病防治策略的制定提供必要的参考依据.
목적　탐토혈지수평여관심병발병적관계. 방법　선택주원학진적관심병환자84례위병례조，배제관심병적주원환자혹건강체검자163례위대조조，대량조적혈지수평、지단백（a）적균수진행비교，병용단인소화다인소분석계산위험인소적우세비（OR）급OR95%가신한（95%CI）. 결과　병례조적총담고순、삼선감유、고밀도 지단백수평분별위4.13，1.79화1.16 mmolAL-1，지단백（a）위0.38 g.L-1，이대 조조혈지삼항위3.82，1.44화1.34 mmolAL-1，지단백（a）위0.16 gAL-1，량조간균유현저적 통계 학차이（P<0.05）; 단인소분석현시: 상술4항지표적OR치분별위3.03， 2.42，3.76 화0.21. 다인소분석결과현시: 피사선진입Logistic회귀방정적변량분별위고밀도지단백、지단백（a）、담고순수평화매일흡연량. 결론　흡연화지대사문란시아국관심병환자적주 요위험인소，아국적담고순수평이국제통일표준작위정상치계한，표준과고. 저사선색장위아국관심병위험인소적심입연구화관심병방치책략적제정제공필요적삼고의거.
AIM　To investigate the relationship between serum lipoprotein and coronary heart disease (CHD). METHODS　84 CHD inpatients were selected as c ase group and 163 non-CHD persons from inpatients or healthy population were defined as control group. Se rum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-c) and Lipop rotein (a) (Lp (a)) were measured. RESULTS　Means of TC, TG, HDL-c and Lp (a) in ca s es were 4.13 mmol*L-1, 1.79 mmol*L-1, 1.16 mmol*L-1 and 0.3 8 g*L-1 respectively, while means of those variable in controls were 3.82 mmol*L-1, 1.44 mmol*L-1, 1.34 mmol*L-1 a nd 0.16 g*L-1. Differences between two groups were significan (P<0.05). Uni-variable analysis indic ated that elevation of TG, TC and Lp (a) and decrease of HDL-c were significan tly related to risk of CHD with Odds Ratio (OR) of 3.03, 2.42, 3.76 and 0.21 respectively. Multi-variable analy sis showed that HDL-c, TC, Lp (a) and consumption of cigarettes per-day were the variables bei ng selected in Logistic equation. CONCLUSION　Dislipidemia and cigarette smokin g might be the major risk factors of coronary heart disease in China and in terms of TC disputed boundary, the international standard is too high for Chinese.