CAJ | 학술논문

目的研究血管内皮生长因子C(VEGF-C)在食管鳞癌中的表达及其与肿瘤淋巴转移和预后的关系.方法运用免疫组化方法检测VEGF-C在72例食管鳞癌组织及其相应正常食管粘膜组织中的表达,经计算机图像分析,计算免疫组化阳性细胞百分率.结果正常食管粘膜中未见VEGF-C抗原的表达,而在72例食管鳞癌组织中有28例阳性表达(38.9%).VEGF-C抗原表达与肿瘤的浸润深度和淋巴结转移密切相关(χ 2=10.77,P＜0.01;χ2=10.98,P＜0.01),但与患者的年龄、肿瘤的大小及分化程度无关.VEGF-C阳性组患者的生存率显著低于VEGF-C阴性组(χ2=-11.16,P＜0.01).结论VEGF-C的表达可促进食管鳞癌的淋巴转移.VEGF-C抗原可作为判断食管鳞癌不良预后的危险因子.
목적연구혈관내피생장인자C(VEGF-C)재식관린암중적표체급기여종류림파전이화예후적관계.방법운용면역조화방법검측VEGF-C재72례식관린암조직급기상응정상식관점막조직중적표체,경계산궤도상분석,계산면역조화양성세포백분솔.결과정상식관점막중미견VEGF-C항원적표체,이재72례식관린암조직중유28례양성표체(38.9%).VEGF-C항원표체여종류적침윤심도화림파결전이밀절상관(χ 2=10.77,P＜0.01;χ2=10.98,P＜0.01),단여환자적년령、종류적대소급분화정도무관.VEGF-C양성조환자적생존솔현저저우VEGF-C음성조(χ2=-11.16,P＜0.01).결론VEGF-C적표체가촉진식관린암적림파전이.VEGF-C항원가작위판단식관린암불량예후적위험인자.
[Objective] To investigate the expression of vascular endothelial growth factor-C (VEGF-C) in esophageal squamous cell carcinoma (ESCC), and the relationship between its expression and the lymphatic metastasis and prognosis. [Methods] Immunohistochemical method was used to examine the expression of VEGF-C in 72cases of the ESCC and adjacent normal esophageal mucosa, and the percentage of the cells positively stained with VEGF-C antibody was calculated with a computer-aided microscopic image analysis system. [Results] VEGF-C antigen was not expressed in normal esophageal mucosa but detected in 28 of 72 (38.9%) neoplastic esophageal lesions. The expression of VEGF-C antigen was significantly associated with the depth of tumor invasion (χ2=10.77, P ＜0.01) and lymph node metastasis(χ2=10.98, P ＜0.01), but not with the patients' age, tumor size or differentiation (P ＞0.05). The overall survival rate of the patients with positive VEGF-C expression was significantly lower than that of the patients without VEGF-C expression (χ2=11.16, P ＜0.01). [Conclusion] The expression of VEGF-C in ESCC can promote tumor lymphatic metastasis, and it may serve as a risk factor indicating a poor prognosis of ESCC.