CAJ | 학술논문

本文回顾了近年来各种不同的年龄相关性黄斑变性(AMD)的实验模型.其中应用最广泛的是激光诱导脉络膜新生血管的形成(CNV),即渗出性AMD的晚期阶段.其它模型有的以本病不同病理表现为基础,如地图样萎缩,drusen形成;有的以引起病变的不同影响因素为基础,如年龄,光线,高脂饮食等.我们希望这篇综述能为研究者们选择合适的AMD模型起到一定参考作用.
본문회고료근년래각충불동적년령상관성황반변성(AMD)적실험모형.기중응용최엄범적시격광유도맥락막신생혈관적형성(CNV),즉삼출성AMD적만기계단.기타모형유적이본병불동병리표현위기출,여지도양위축,drusen형성;유적이인기병변적불동영향인소위기출,여년령,광선,고지음식등.아문희망저편종술능위연구자문선택합괄적AMD모형기도일정삼고작용.
This article reviews different experimental models of age-related macular degeneration (AMD) used in recent studies. The most widely used one is Laser-induced choroidal neovascularization (CNV), which represents the late severe stage in the exudative form of AMD. Other models are based on several different pathogenesis, like geographic atrophy,drusen formation or multifactorial effects, like age, light, highfat, etc. It is hoped that this review could become a good reference for researchers who need to choose suitable models for AMD study.