CAJ | 학술논문

目的通过对碳酸锂联合131Ⅰ治疗的Graves病患者不同时期甲状腺激素水平测定、临床症状体征的改善情况,评价治疗效果.方法将肾功能正常的68例Graves病患者分为A组(131Ⅰ+碳酸锂)、B组(131Ⅰ),于131Ⅰ治疗0、14d和6个月回访,测定FT3、FT4和TSH值,并进行统计学分析.结果 A、B两组治疗早期甲状腺激素水平、临床症状、体征及早发甲状腺功能减退发生率有明显差异,而治愈率无明显差异.结论肾功能正常时,使用碳酸锂联合131Ⅰ治疗Graves病,可以减少131Ⅰ剂量,改善治疗初期甲状腺功能,减少早发甲低的可能性.
목적 통과대탄산리연합131Ⅰ치료적Graves병환자불동시기갑상선격소수평측정、림상증상체정적개선정황,평개치료효과.방법 장신공능정상적68례Graves병환자분위A조(131Ⅰ+탄산리)、B조(131Ⅰ),우131Ⅰ치료0、14d화6개월회방,측정FT3、FT4화TSH치,병진행통계학분석.결과 A、B량조치료조기갑상선격소수평、림상증상、체정급조발갑상선공능감퇴발생솔유명현차이,이치유솔무명현차이.결론 신공능정상시,사용탄산리연합131Ⅰ치료Graves병,가이감소131Ⅰ제량,개선치료초기갑상선공능,감소조발갑저적가능성.
Objective To evaluate the therapeutic effects of 131Ⅰ combined with lithium carbonate in the treatment of Graves by detecting the levels of thyroid hormones and observing the improve- ment of clinical symptoms and signs at different stages. Methods 68 cases of Graves patients with normal renal function were divided into group A (treated with 131Ⅰ and lithium carbonate) and group B (treated with 131Ⅰ alone). The plasma levels of FT3,FT4 and TSH were detected during the day of treatment,14 days and 6 months after the treatment. All data were analyzed with statistical method. Results There were significant differences in the levels of thyroid hormones, clinical symptoms,signs and the incidence of early hypothyroidism between the two groups but the curative ratio had not significant difference. Conclusion Combination of 131Ⅰ with lithium carbonate in the treatment of Graves can decrease the dose of 131Ⅰ,improve thyroid function at the early stage of treatment and reduce the possibility of early hypothyroidism.