CAJ | 학술논문

背景:气管损伤缝合与新型人工气管的研制都需要了解气管软骨的拉伸力学特性以修复、重建气管功能.以往的国内外研究对人工气管的生物力学报道较多,而对人气管软骨生物力学的报道较少.目的:以一维拉伸实验方法观察气管软骨的力学性质.方法:正常人新鲜尸体气管标本2个,标本获取征得家属同意.取出标本,在常温下解冻,以手术刀切取气管软骨试样标本加工成试样长度25 mm,宽度5 mm,厚度1.8～2.2 mm试样20个,在日本岛津电子万能试验机上对20个气管软骨试样进行一维拉伸实验,拉伸实验速度为5 mm/min.观察试件拉伸最大载荷、最大位移、最大应力、最大应变、弹性模量、应力-应变曲线.结果与结论:人尸体气管软骨最大载荷为(60.946±10.377)N,最大位移为(1.973±0.159)mm,最大应力为(6.229±1.125)MPa,最大应变为(32.825±2.776)%.气管软骨的应力-应变曲线为指数关系变化的,曲线最初的低坡部分是由于施加拉力的方向与胶原蛋白结构的排列一致,曲线的陡峭部分代表胶原蛋白本身的拉伸刚度.为描述气管软骨一维拉伸中的应力应变关系,对气管软骨实验数据各取15个点应力-应变数据采用多项式,以最小二乘法进行拟合,得出应力(δ)-应变(ε)关系式:σ(ε)=-0.1 11 3e~5+1.602 1e~4-7.821 6e~3+17.995 1e~2+3.624e.实验结果显示,气管软骨具有较强的承受载荷和抵抗变形能力,反映其具有黏性又有弹性的黏弹性力学特性,支持软骨的力学性质与软骨胶原含量呈正相关的观点.
배경:기관손상봉합여신형인공기관적연제도수요료해기관연골적랍신역학특성이수복、중건기관공능.이왕적국내외연구대인공기관적생물역학보도교다,이대인기관연골생물역학적보도교소.목적:이일유랍신실험방법관찰기관연골적역학성질.방법:정상인신선시체기관표본2개,표본획취정득가속동의.취출표본,재상온하해동,이수술도절취기관연골시양표본가공성시양장도25 mm,관도5 mm,후도1.8～2.2 mm시양20개,재일본도진전자만능시험궤상대20개기관연골시양진행일유랍신실험,랍신실험속도위5 mm/min.관찰시건랍신최대재하、최대위이、최대응력、최대응변、탄성모량、응력-응변곡선.결과여결론:인시체기관연골최대재하위(60.946±10.377)N,최대위이위(1.973±0.159)mm,최대응력위(6.229±1.125)MPa,최대응변위(32.825±2.776)%.기관연골적응력-응변곡선위지수관계변화적,곡선최초적저파부분시유우시가랍력적방향여효원단백결구적배렬일치,곡선적두초부분대표효원단백본신적랍신강도.위묘술기관연골일유랍신중적응력응변관계,대기관연골실험수거각취15개점응력-응변수거채용다항식,이최소이승법진행의합,득출응력(δ)-응변(ε)관계식:σ(ε)=-0.1 11 3e~5+1.602 1e~4-7.821 6e~3+17.995 1e~2+3.624e.실험결과현시,기관연골구유교강적승수재하화저항변형능력,반영기구유점성우유탄성적점탄성역학특성,지지연골적역학성질여연골효원함량정정상관적관점.
BACKGROUND:Tracheal injury suture and the development of a new tracheal prosthesis all need to understand the tensile mechanical properties of tracheal cartilage.so as to repair and rebuild tracheal function.Previous researches on the biomechanics of artificial trachea are many reported.while the biomechanics of human tracheal cartilage is reported less.OBJECTIVE:To investigate the mechanical properties of tracheal cartilage using one-dimensional tensile test method.METHODS:Two fresh cadaver specimens of normal human trachea.with the informed consents of their families.were involved.The specimens were thaw at room temperature,and then tracheal cartilage specimens were cut using scalpel into 20 samples at the length of 25 mm,width 5 mm,thickness 1.8-2.2 mm.The 20 tracheal cartilage samples were subjected to one-dimensional tensile test with Shimadzu electronic universal testing machine Japan,at the tensile test speed of 5 mm/min.The tensile maximum load,maximum displacement,maximum stress,maximum strain,elastic modulus and stress-strain curve of the specimens were observed.RESULTS AND CONCLUSION:The maximum load of human cadaver tracheal cartilage was(60 946±10.377)N,maximumdisplacementwas(1.973±0.159)mm,maximum stresswas(6.229±1.125)Mpa,maximum strainwas(32.825±2.776)%.Tracheal cartilage stress-strain curves was changed along with the index,the initial low slope of the curye was due to the direction of imposed tension was similar with the arrangement of collagen structure,the steep slope represented the tensile strength of collagen.To describe the tracheal cartilage stress-strain relationship in a one-dimensional tension,15 stress-strain data of the tracheal cartilage experimental data adopted polynomial by the least square fitting method,to obtain stress(δ)-strain(ε)relationship forrnula:σ(ε)=-0.111 3e~5+1.602 1e~4-7.821 6e~3+17.995 1e~2+3.624e.It is indicated that tracheal cartilage has a strong capacity to bear Joad and resist deformation,reflecting their viscoelastic mechanical properties of both flexibility and viscosity,supporting that the mechanical properties of cartilage is positively related to cartilage collagen content.