CAJ | 학술논문

背景:聚乙烯醇水凝胶目前普遍被认为是一种在临床上非常有前途的关节软骨替代材料.聚酰胺66是一种具有高强度、高韧性和良好稳定性的聚合物,在工程和医学领域已获得广泛应用.聚氨酯具有良好的组织相容性和血液相容性,在合成材料中,聚氨酯在软骨修复方面表现出其独特的优势.目的:比较多孔网状聚乙烯醇,聚氨酯,聚酰胺66生物材料修复兔关节软骨缺损的效果,探索性能更加优异的软骨支架材料.方法:在36只兔髌股关节面上制造软骨缺损模型后按随机数字表法分为4组,每组9只.聚乙烯醇植入组、聚氨酯植入组、聚酰胺66植入组分别在软骨缺损处相应植入生物材料,对照组不做任何处理.植入4,8,12周后观察兔行为形态及膝关节局部组织形态学变化,对植入后12周修复组织进行组织学评分.结果与结论:生物材料植入后兔大体形态观察伤口无感染,关节活动度好.植入后12周,植入组材料与周边组织融为一体,周边软骨未见明显退行性变:对照组整个观察期内,修复区表面不平整,与周围软骨分界清楚,有纤维状物覆盖.组织学评分显示聚乙烯醇植入组与聚氨酯植入组差异无显著性意义(P>0.05),优于聚酰胺66植入组及对照组(P<0.05).提示多孔聚乙烯醇,聚氨酯生物材料具有良好的组织相容性及替代关节软骨的功能.
배경:취을희순수응효목전보편피인위시일충재림상상비상유전도적관절연골체대재료.취선알66시일충구유고강도、고인성화량호은정성적취합물,재공정화의학영역이획득엄범응용.취안지구유량호적조직상용성화혈액상용성,재합성재료중,취안지재연골수복방면표현출기독특적우세.목적:비교다공망상취을희순,취안지,취선알66생물재료수복토관절연골결손적효과,탐색성능경가우이적연골지가재료.방법:재36지토빈고관절면상제조연골결손모형후안수궤수자표법분위4조,매조9지.취을희순식입조、취안지식입조、취선알66식입조분별재연골결손처상응식입생물재료,대조조불주임하처리.식입4,8,12주후관찰토행위형태급슬관절국부조직형태학변화,대식입후12주수복조직진행조직학평분.결과여결론:생물재료식입후토대체형태관찰상구무감염,관절활동도호.식입후12주,식입조재료여주변조직융위일체,주변연골미견명현퇴행성변:대조조정개관찰기내,수복구표면불평정,여주위연골분계청초,유섬유상물복개.조직학평분현시취을희순식입조여취안지식입조차이무현저성의의(P>0.05),우우취선알66식입조급대조조(P<0.05).제시다공취을희순,취안지생물재료구유량호적조직상용성급체대관절연골적공능.
BACKGROUND: Polyvinyl alcohol hydrogel (PVA) has been generally considered as a good substitute material of articular cartilage. Polyamide 66 (PA66) polymer has achieved an extensive application in the fields of engineering and medicine owing to its high intensity, strong tenacity and good stability. Polyurethanes exhibit good histocompatibility and blood compatibility and show distinct advantages in repairing cartilage.OBJECTIVE: To compare the outcomes of repairing articular cartilage defects in rabbit knee joints with three materials and to find the best material.METHODS: Thirty-six healthy adult New Zealand rabbits were prepared for the models of articular cartilage defects by perforating on the patellofemoral joint and randomly divided into 4 groups, with 9 animals in each group. PVA, polyurethane, and PA66 were implanted into the into articular cartilage defects in rabbits of corresponding groups. There was no treatment in the control group.The macroscopic and histological evaluations of rabbit knee joints were performed at 4, 8 and 12 weeks postoperatively. The score of histology was used to evaluate the repairs of articular cartilage defects at 12 weeks postoperatively.RESULTS AND CONCLUSION: No infection was observed in all animals with good motion of joints. At 12 weeks postoperatively, the materials got well with surrounding cartilage, which did not degenerate obviously. The defects in the control group were filled with fibrous scar-like tissues that arranged in disorder. The histological score of the in the group implanted by PVA, as well as polyurethane, was higher than that in PA66 and the control groups (P < 0.05), but the difference between the two groups had no significance (P>0.05).The porous materials PVA and polyurathane have good function for replacing articular cartilage, with good biocompatibility.