CAJ | 학술논문

目的探讨急性呼吸道感染患者血清载酯蛋白A-I(ApoA-I)变化及临床意义.方法 2006年12月至2007年7月入住上海交通大学附属第一人民医院急诊ICU及急诊观察室急性呼吸道感染患者为试验组(44例),根据降钙素原(PCT)的质量浓度进行分组,分为PCT＜0.5 ng/ml组,0.5ng/ml∧≤PCT＜2 ng/ml组,PCT≥2 ng/ml组.41例健康体检者为对照组.试验组和对照组均在入院24h内测定静脉血中ApoA-I、PCT、C反应蛋白(CRP)和白蛋白水平.统计学方法计量资料用均数±标准差(x±s)表示,应用SPSS 12.0软件进行统计学分析,计量资料的比较采用t检验及方差分析,相关性分析采用直线相关分析,P＜0.05为差异具有统计学意义.结果随着PCT质量浓度增加,ApoA-I和血清白蛋白值越低而CRP值越高(P＜0.05).结论 ApoA-I与呼吸道感染的严重程度呈正相关,在较严重的呼吸道感染ApoA-I具有一定的诊断价值,表明这类患者存在脂质代谢紊乱.
목적 탐토급성호흡도감염환자혈청재지단백A-I(ApoA-I)변화급림상의의.방법 2006년12월지2007년7월입주상해교통대학부속제일인민의원급진ICU급급진관찰실급성호흡도감염환자위시험조(44례),근거강개소원(PCT)적질량농도진행분조,분위PCT＜0.5 ng/ml조,0.5ng/ml∧≤PCT＜2 ng/ml조,PCT≥2 ng/ml조.41례건강체검자위대조조.시험조화대조조균재입원24h내측정정맥혈중ApoA-I、PCT、C반응단백(CRP)화백단백수평.통계학방법계량자료용균수±표준차(x±s)표시,응용SPSS 12.0연건진행통계학분석,계량자료적비교채용t검험급방차분석,상관성분석채용직선상관분석,P＜0.05위차이구유통계학의의.결과 수착PCT질량농도증가,ApoA-I화혈청백단백치월저이CRP치월고(P＜0.05).결론 ApoA-I여호흡도감염적엄중정도정정상관,재교엄중적호흡도감염ApoA-I구유일정적진단개치,표명저류환자존재지질대사문란.
Objective To investigate the changes of serum apolipoprotein A-I and its clinical significance to acute respiratory infection.Method Totally 44 patients with acute respiratory infection were divided into three groups according to various concentration of Serum apolipoprotein A-I.They were procaleitonin(PCT)＜0.5 ng/ml group,0.5 ng/ml≤PCT＜2 ng/ml group and PCT≥2 ng/ml group.We measured apolipoprotein A-I,C-reactive protein,procalcitonin and albumin within 24 hours after admission.Results With the increase of serumPCT,the production of ApoA-I and albumin were down-regulated,while CRP up-regulated.Conclusions Apolipoprotein A-I has a sound relationship with the acute respiratory infection.It can be used as one of the diagnostic criteria in severe infection patients who have disorders of lipometabolism.