CAJ | 학술논문

目的研究肝癌中转胶蛋白(Transgelin)表达预测肝癌切除术患者复发及预后的临床意义.方法应用组织芯片结合免疫组织化学染色检测43例肝癌切除术患者肝癌和癌周组织的Transgelin表达水平.以Logrank检验、Kaplan-Meier分析以及多因素Cox回归分析其表达水平与肝癌患者预后的关系.结果 Transgelin在肝癌组织中的表达明显高于癌旁组织,Transgelin在癌组织中的表达与肿瘤大小、门静脉癌栓、肿瘤TNM分期以及术前血清AFP水平呈正相关性.Transgelin阳性表达的患者术后无瘤生存率明显低于阴性表达者(P＜0.01).多因素Cox回归分析显示,Transgelin是影响术后无瘤生存率的独立预后因素之一(P＜0.01).结论 Transgelin与肝癌患者术后复发密切相关,可作为判断肝癌切除术预后的生物标志物.
목적 연구간암중전효단백(Transgelin)표체예측간암절제술환자복발급예후적림상의의.방법 응용조직심편결합면역조직화학염색검측43례간암절제술환자간암화암주조직적Transgelin표체수평.이Logrank검험、Kaplan-Meier분석이급다인소Cox회귀분석기표체수평여간암환자예후적관계.결과 Transgelin재간암조직중적표체명현고우암방조직,Transgelin재암조직중적표체여종류대소、문정맥암전、종류TNM분기이급술전혈청AFP수평정정상관성.Transgelin양성표체적환자술후무류생존솔명현저우음성표체자(P＜0.01).다인소Cox회귀분석현시,Transgelin시영향술후무류생존솔적독립예후인소지일(P＜0.01).결론 Transgelin여간암환자술후복발밀절상관,가작위판단간암절제술예후적생물표지물.
Objective To study the clinical meaning of Transgelin expression in heptacellular carcinoma(HCC) in prognosing recurrence after hepatectomy. Methods The expression of Transgelin in cancerous lesions and tissue adjacent to cancer lesions from 223 operation samples was detected by immunohistochemical staining combined with tissue microarray techniques. The correlation between the level of Transgelin expression and the prognosis was analyzed by means of log- rank test, Kaplan- Meier analysis and multivariate Cox regression analysis. Results Transgelin was higher expressed in tumor tissue than in tissue adjacent to cancer lesions. Transgelin was positively correlated with the presence of tumor size, portal vein invasion, pTNM tumor stages and serum AFP level. Patients with positive expression of Transgelin had worse tumor free survival than those with negative ones (P ＜0. 01). The multivariate Cox regression analysis showed that Transgelin expression level was one of the independent prognostic factors in tumor free survival after surgery. Conclusions The expression of Transgelin in hepatocellular carcinoma was significantly associated with recurrence in patients with HCC after hepatectomy, and this protein could be the biomarker of the prognosis in HCC surgery.