中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2008年
1期
80-85
,共6页
毕颖文%陈荣家%钱江%姚亦群%袁一飞%李霞萍
畢穎文%陳榮傢%錢江%姚亦群%袁一飛%李霞萍
필영문%진영가%전강%요역군%원일비%리하평
眶肿瘤%淋巴瘤%分类法%病理学,临床%治疗
眶腫瘤%淋巴瘤%分類法%病理學,臨床%治療
광종류%림파류%분류법%병이학,림상%치료
Orbital neoplasms%Lymphoma%Classification%Pathology,Clinical%Therapy
目的 初步探讨根据WHO淋巴造血系统肿瘤新分类标准对眼眶淋巴瘤进行分型及分析不同类型眼眶淋巴瘤的临床病理特点.方法 收集2002年1月至2006年6月经手术和组织病理学检查确诊的78例眼眶淋巴瘤患者的临床和病理资料,根据WHO淋巴造血系统肿瘤新分类标准进行分类,进一步分析其临床病理特点,治疗方案及预后.结果 78例眼眶淋巴瘤均为非霍奇金淋巴瘤(NHL),其中77例为B细胞来源(98.7%),包括黏膜相关淋巴组织边缘区B细胞淋巴瘤(MALT淋巴瘤)71例(91.0%),髓外浆细胞瘤3例(3.8%),滤泡性淋巴瘤1例(1.3%),弥漫大B细胞淋巴瘤1例(1.3%),前驱B淋巴母细胞性淋巴瘤1例(1.3%);1例为T细胞来源,为非特殊性周围T细胞性淋巴瘤(1.3%).MALT淋巴瘤经局部放疗后肿瘤明显消退,孤立性髓外浆细胞瘤经局部放疗后病情稳定,滤泡性淋巴瘤和弥漫大B细胞淋巴瘤行全身化疗和局部放疗后病情得到控制.前驱B淋巴母细胞性淋巴瘤和非特殊性周围T细胞性淋巴瘤恶性程度较高,患者均于短期内死亡.结论 眼眶淋巴瘤因其类型不同而恶性程度和临床表现不同,治疗和预后也各异,故根据WHO淋巴造血系统肿瘤新分类标准对眼眶淋巴瘤进行分类具有重要意义.
目的 初步探討根據WHO淋巴造血繫統腫瘤新分類標準對眼眶淋巴瘤進行分型及分析不同類型眼眶淋巴瘤的臨床病理特點.方法 收集2002年1月至2006年6月經手術和組織病理學檢查確診的78例眼眶淋巴瘤患者的臨床和病理資料,根據WHO淋巴造血繫統腫瘤新分類標準進行分類,進一步分析其臨床病理特點,治療方案及預後.結果 78例眼眶淋巴瘤均為非霍奇金淋巴瘤(NHL),其中77例為B細胞來源(98.7%),包括黏膜相關淋巴組織邊緣區B細胞淋巴瘤(MALT淋巴瘤)71例(91.0%),髓外漿細胞瘤3例(3.8%),濾泡性淋巴瘤1例(1.3%),瀰漫大B細胞淋巴瘤1例(1.3%),前驅B淋巴母細胞性淋巴瘤1例(1.3%);1例為T細胞來源,為非特殊性週圍T細胞性淋巴瘤(1.3%).MALT淋巴瘤經跼部放療後腫瘤明顯消退,孤立性髓外漿細胞瘤經跼部放療後病情穩定,濾泡性淋巴瘤和瀰漫大B細胞淋巴瘤行全身化療和跼部放療後病情得到控製.前驅B淋巴母細胞性淋巴瘤和非特殊性週圍T細胞性淋巴瘤噁性程度較高,患者均于短期內死亡.結論 眼眶淋巴瘤因其類型不同而噁性程度和臨床錶現不同,治療和預後也各異,故根據WHO淋巴造血繫統腫瘤新分類標準對眼眶淋巴瘤進行分類具有重要意義.
목적 초보탐토근거WHO림파조혈계통종류신분류표준대안광림파류진행분형급분석불동류형안광림파류적림상병리특점.방법 수집2002년1월지2006년6월경수술화조직병이학검사학진적78례안광림파류환자적림상화병리자료,근거WHO림파조혈계통종류신분류표준진행분류,진일보분석기림상병리특점,치료방안급예후.결과 78례안광림파류균위비곽기금림파류(NHL),기중77례위B세포래원(98.7%),포괄점막상관림파조직변연구B세포림파류(MALT림파류)71례(91.0%),수외장세포류3례(3.8%),려포성림파류1례(1.3%),미만대B세포림파류1례(1.3%),전구B림파모세포성림파류1례(1.3%);1례위T세포래원,위비특수성주위T세포성림파류(1.3%).MALT림파류경국부방료후종류명현소퇴,고립성수외장세포류경국부방료후병정은정,려포성림파류화미만대B세포림파류행전신화료화국부방료후병정득도공제.전구B림파모세포성림파류화비특수성주위T세포성림파류악성정도교고,환자균우단기내사망.결론 안광림파류인기류형불동이악성정도화림상표현불동,치료화예후야각이,고근거WHO림파조혈계통종류신분류표준대안광림파류진행분류구유중요의의.
Objeetive To investigate the orbital lymphoma subtypes according to the new classification of the World Health Organization(WHO)and analyze the clinicopathologic features of the different type of orbital lymphoma.Methods A total of 78 cases of orbital lymphoma treated and diagnosed at EENT hospital from January 2002 to June 2006 have been classified using the WHO classification of lymphoma and analyze their clinicopathologic features,treatment and prognoses.Results All the 78 cases were confirmed to be nonHodgkin lymphoma and 77 cases(98.7%)were of B-cell lineage.Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue(MALT lymphoma)is the most commonest(71 case,91.0%),followed by extramedullary plasmacytoma(3 cases,3.8%),follicular lymphoma(1 case,1.3%),diffuse large B-cell lymphoma(1 case,1.3%),precursor B-lymphoblastic lymphoma(1 case,1.3%).1 case(1.3%)of T-cell lineage was peripheral T-cell lymphoma.MALT lymphoma of orbit showed gradual regression treated with local radiotherapy and have a favorable prognosis.Solitarullary plasmacytoma responded to local radiation alone and had no recurrence.Follicular lymphoma and diffuse large B-cell lymphoma responded to local radiation and systemic chemotherapy without disease aggression.The patient of precursor B-lymphoblastic lymphoma and peripheral T-cell lymphoma died of progression of the disease in a short time.Conclusions Various types of lymphoma have different degree of malignancy,clinical manifestation,treatment and prognosis,so the classification of orbital lymphoma is very important.