国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2012年
5期
328-330
,共3页
GPR119%激动剂%葡萄糖刺激的胰岛素分泌%胰高血糖素样肽-1%胰岛β细胞
GPR119%激動劑%葡萄糖刺激的胰島素分泌%胰高血糖素樣肽-1%胰島β細胞
GPR119%격동제%포도당자격적이도소분비%이고혈당소양태-1%이도β세포
GPR119%Agonists%Glucose-stimulated insulin secretion%Glucagon-like peptide-1%Islet β cell
糖尿病病程中出现的胰岛β细胞功能衰竭和降糖药物引起的低血糖已成为糖尿病治疗的难点.应用G蛋白耦联受体119(GPR119)激动剂可以降低血糖水平,保护胰岛β细胞功能,且不产生低血糖.GPR119在胰岛β细胞和肠内分泌细胞中表达,其激活可增加葡萄糖刺激的胰岛素分泌( GSIS)和胰高血糖素样肽-t(GLP-1)的分泌,并增强胰岛素启动子的活性.GPR119激动剂表现出的诸多优势提示,其作为一类新的糖尿病治疗药物有良好的应用前景.
糖尿病病程中齣現的胰島β細胞功能衰竭和降糖藥物引起的低血糖已成為糖尿病治療的難點.應用G蛋白耦聯受體119(GPR119)激動劑可以降低血糖水平,保護胰島β細胞功能,且不產生低血糖.GPR119在胰島β細胞和腸內分泌細胞中錶達,其激活可增加葡萄糖刺激的胰島素分泌( GSIS)和胰高血糖素樣肽-t(GLP-1)的分泌,併增彊胰島素啟動子的活性.GPR119激動劑錶現齣的諸多優勢提示,其作為一類新的糖尿病治療藥物有良好的應用前景.
당뇨병병정중출현적이도β세포공능쇠갈화강당약물인기적저혈당이성위당뇨병치료적난점.응용G단백우련수체119(GPR119)격동제가이강저혈당수평,보호이도β세포공능,차불산생저혈당.GPR119재이도β세포화장내분비세포중표체,기격활가증가포도당자격적이도소분비( GSIS)화이고혈당소양태-t(GLP-1)적분비,병증강이도소계동자적활성.GPR119격동제표현출적제다우세제시,기작위일류신적당뇨병치료약물유량호적응용전경.
Islet β cell failure during diabetic progression and hypoglycemia induced by anti-diabetic drugs have become the obstacles of diabetes treatment.G protein coupled receptor 119 ( GPR119) agonists can decrease blood glucose level and preserve islet β cell function without hypoglycemia.GPR119 is expressed both in islet β cells and enteroendocrine cells,and activation of GPR119 can enhance glucose-stimulated insulin secretion (GSIS),increase the secretion of glucagon-like peptide-1 ( GLP-1 ),and promote the activation of insulin promoter.These advantages mentioned above suggest that GPR119 agonists show a good prospect as a new kind of anti-diabetes drugs.
