中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
4期
464-465
,共2页
尼可地尔%心绞痛%疗效
尼可地爾%心絞痛%療效
니가지이%심교통%료효
Nicorandil%Angina pectoris%Therapeutic effect
目的 观察尼可地尔治疗心绞痛的疗效.方法 将155例心绞痛患者随机分为治疗组(85例)和对照组(70例),两组均常规服用阿司匹林0.1 g/d,氯吡格雷50 mg/d,单硝酸异山梨酯50 mg/d,辛伐他汀40 mg/d,有高血压或糖尿病者别予控制血压及血糖,有心衰者予适当利尿等减轻心脏负荷,治疗组在常规基础上加用尼可地尔5 mg,3次/d,1个月为一疗程.两组均治疗1个疗程.结果 治疗组显效32例,有效34例,无效14例,总有效率为82.5%;对照组显效23例,有效28例,无效24例,总有效率为67.0%.两组总有效差异有统计学意义(x2=4.40,P＜0.05).两组除有少数患者出现轻度头晕外,未见其它明显不良反应.结论 尼可地尔治疗心绞痛疗效好,无明显不良反应.
目的 觀察尼可地爾治療心絞痛的療效.方法 將155例心絞痛患者隨機分為治療組(85例)和對照組(70例),兩組均常規服用阿司匹林0.1 g/d,氯吡格雷50 mg/d,單硝痠異山梨酯50 mg/d,辛伐他汀40 mg/d,有高血壓或糖尿病者彆予控製血壓及血糖,有心衰者予適噹利尿等減輕心髒負荷,治療組在常規基礎上加用尼可地爾5 mg,3次/d,1箇月為一療程.兩組均治療1箇療程.結果 治療組顯效32例,有效34例,無效14例,總有效率為82.5%;對照組顯效23例,有效28例,無效24例,總有效率為67.0%.兩組總有效差異有統計學意義(x2=4.40,P＜0.05).兩組除有少數患者齣現輕度頭暈外,未見其它明顯不良反應.結論 尼可地爾治療心絞痛療效好,無明顯不良反應.
목적 관찰니가지이치료심교통적료효.방법 장155례심교통환자수궤분위치료조(85례)화대조조(70례),량조균상규복용아사필림0.1 g/d,록필격뢰50 mg/d,단초산이산리지50 mg/d,신벌타정40 mg/d,유고혈압혹당뇨병자별여공제혈압급혈당,유심쇠자여괄당이뇨등감경심장부하,치료조재상규기출상가용니가지이5 mg,3차/d,1개월위일료정.량조균치료1개료정.결과 치료조현효32례,유효34례,무효14례,총유효솔위82.5%;대조조현효23례,유효28례,무효24례,총유효솔위67.0%.량조총유효차이유통계학의의(x2=4.40,P＜0.05).량조제유소수환자출현경도두훈외,미견기타명현불량반응.결론 니가지이치료심교통료효호,무명현불량반응.
Objective To observe the therapeutic effect of nicorandil in treatment of angina pectoris. Methods 155 cases of angina pectoris patients were randomly divided into the therapeutic group(85 cases)and control group(70 cases),both of which took normal doses of aspirin vitamin C effervescent tablets 0.1g/day,clopidogrel 50mg/day,elantan 50mg/day and simvastatin 40mg/day,where hypertensions or diabetics were given blood pressure and sugar control and heart failure patients were given proper diuretic therapy and other methods to release heart Ioad.Patients in the therapeutic group were additionally given 5 mg nicorandil,3 times/day.The two groups were both given one period of treatment about one month. Results In therapeutic group,32 cases had significant therapeutic effectiveness,34 cases had effectiveness and 14 cases had no effectiveness with a total effective rate of 82.5%.In the control group,23 cases had significant therapeutic effectiveness,28 cases had effectiveness and 24 cases had no effectiveness with a total effective rate of 67.0%.The comparative difference of the total effectiveness of the twogroups had statistical significance(x2 =4.40,P＜0.05).No other significant adverse reaction was found except several cases of light dizzy in the two groups. Conclusion Nicorandil has good therapeutic effective in treatment of angina pectoris and no significant adverse reaction.
