中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2012年
6期
495-497
,共3页
沈文清%邢艳芳%钱捷%梁敏灵%黄丽
瀋文清%邢豔芳%錢捷%樑敏靈%黃麗
침문청%형염방%전첩%량민령%황려
糖尿病肾病%脂蛋白(a)%C反应蛋白%载脂蛋白类
糖尿病腎病%脂蛋白(a)%C反應蛋白%載脂蛋白類
당뇨병신병%지단백(a)%C반응단백%재지단백류
Diabetic nephropathies%Lipoprotein(a)%C-reactive protein%Apolipoproteins
目的 检测2型糖尿病患者血清中半胱氨酸蛋白酶抑制剂C(CysC)、脂蛋白(a)[LP(a)]、载脂蛋白A1 (ApoA1)、载脂蛋白B(ApoB)和超敏C反应蛋白(hs- CRP)水平,并探讨其临床意义.方法 96例2型糖尿病患者分为单纯糖尿病组50例、糖尿病肾病组46例,另选择50例健康体检者作为对照组,分别检测各组血清中的CysC、Lp(a)、ApoA1、ApoB以及hs-CRP水平.结果 2型糖尿病组与对照组比较,CysC[(0.95±0.16)mg/L对(0.46±0.17)mg/L,P<0.01]、LP(a) [(214.8±182.3)mg/L对(113.1±76.2)mg/L,P<0.01]、hs- CRP[(2.57±1.84)mg/L对(1.07±0.38)mg/L,P<0.01]、ApoB[(1.12±0.18)g/L对(0.81±0.15)g/L,P<0.01]水平均升高;而ApoA1水平降低[(1.02±0.17)g/L对(1.27±0.14)g/L,P<0.01].糖尿病肾病组CysC(2.14±0.68)mg/L、Lp(a)(455.6±263.5)mg/L、hs- CRP(7.24±4.55)mg/L、ApoB(1.22±0.17)g/L,均高于单纯糖尿病组(均P<0.01).2型糖尿病患者尿微量白蛋白与hs- CRP (r=0.478,P<0.01)、CysC(r=0.55,P<0.05)、Lp(a) (r=0.487,P<0.05)、ApoB(r=0.505,P<0.05)呈正相关,与ApoA1(r=-0.52,P<0.05)呈负相关.结论 CysC、Lp(a)、hsCRP、载脂蛋白可作为诊断糖尿病早期肾损害的敏感指标,联合检测更具实用价值.
目的 檢測2型糖尿病患者血清中半胱氨痠蛋白酶抑製劑C(CysC)、脂蛋白(a)[LP(a)]、載脂蛋白A1 (ApoA1)、載脂蛋白B(ApoB)和超敏C反應蛋白(hs- CRP)水平,併探討其臨床意義.方法 96例2型糖尿病患者分為單純糖尿病組50例、糖尿病腎病組46例,另選擇50例健康體檢者作為對照組,分彆檢測各組血清中的CysC、Lp(a)、ApoA1、ApoB以及hs-CRP水平.結果 2型糖尿病組與對照組比較,CysC[(0.95±0.16)mg/L對(0.46±0.17)mg/L,P<0.01]、LP(a) [(214.8±182.3)mg/L對(113.1±76.2)mg/L,P<0.01]、hs- CRP[(2.57±1.84)mg/L對(1.07±0.38)mg/L,P<0.01]、ApoB[(1.12±0.18)g/L對(0.81±0.15)g/L,P<0.01]水平均升高;而ApoA1水平降低[(1.02±0.17)g/L對(1.27±0.14)g/L,P<0.01].糖尿病腎病組CysC(2.14±0.68)mg/L、Lp(a)(455.6±263.5)mg/L、hs- CRP(7.24±4.55)mg/L、ApoB(1.22±0.17)g/L,均高于單純糖尿病組(均P<0.01).2型糖尿病患者尿微量白蛋白與hs- CRP (r=0.478,P<0.01)、CysC(r=0.55,P<0.05)、Lp(a) (r=0.487,P<0.05)、ApoB(r=0.505,P<0.05)呈正相關,與ApoA1(r=-0.52,P<0.05)呈負相關.結論 CysC、Lp(a)、hsCRP、載脂蛋白可作為診斷糖尿病早期腎損害的敏感指標,聯閤檢測更具實用價值.
목적 검측2형당뇨병환자혈청중반광안산단백매억제제C(CysC)、지단백(a)[LP(a)]、재지단백A1 (ApoA1)、재지단백B(ApoB)화초민C반응단백(hs- CRP)수평,병탐토기림상의의.방법 96례2형당뇨병환자분위단순당뇨병조50례、당뇨병신병조46례,령선택50례건강체검자작위대조조,분별검측각조혈청중적CysC、Lp(a)、ApoA1、ApoB이급hs-CRP수평.결과 2형당뇨병조여대조조비교,CysC[(0.95±0.16)mg/L대(0.46±0.17)mg/L,P<0.01]、LP(a) [(214.8±182.3)mg/L대(113.1±76.2)mg/L,P<0.01]、hs- CRP[(2.57±1.84)mg/L대(1.07±0.38)mg/L,P<0.01]、ApoB[(1.12±0.18)g/L대(0.81±0.15)g/L,P<0.01]수평균승고;이ApoA1수평강저[(1.02±0.17)g/L대(1.27±0.14)g/L,P<0.01].당뇨병신병조CysC(2.14±0.68)mg/L、Lp(a)(455.6±263.5)mg/L、hs- CRP(7.24±4.55)mg/L、ApoB(1.22±0.17)g/L,균고우단순당뇨병조(균P<0.01).2형당뇨병환자뇨미량백단백여hs- CRP (r=0.478,P<0.01)、CysC(r=0.55,P<0.05)、Lp(a) (r=0.487,P<0.05)、ApoB(r=0.505,P<0.05)정정상관,여ApoA1(r=-0.52,P<0.05)정부상관.결론 CysC、Lp(a)、hsCRP、재지단백가작위진단당뇨병조기신손해적민감지표,연합검측경구실용개치.
Objective To study the clinical significances of serum lipoprotein (LP),high sensitivity C- reactive protein (hs CRP),cystatin (Cys-C),apolipoprotein (Apo) in type 2 diabetic mellitus (T2DM) patients with early renal impairment.Methods Totally 96 patients were divided into two groups:50 cases in simple diabetic group (DM) aged 60-73 years,46 cases in diabetic nephropathy group (DN) aged 61-72 years,and 50 healthy persons as normal control group aged 61-68 years.Serum levels of LP(a),hs-CRP,Cys-C,ApoA1 and ApoB were detected.Results Serum levels of LP (a) [(214.8±182.3) mg/L vs.(113.1±76.2) mg/L],Cys-C[(0.95±0.16)mg/L vs.(0.46±0.17) mg/L],hs-CRP (2.57± 1.84) mg/L vs.(1.07±0.38)mg/L] and ApoB [(1.12±0.18) g/L vs.(0.81 ±0.15) g/L ]were higher in T2DM patients than in normal control group(all P<0.01),while ApoA1 level was lower than in control[(1.02±0.17)g/L vs.(1.27±0.14)g/L,P< 0.01].The levels of LP (a) (455.6 ± 263.5 ) mg/L,Cys-C (2.14 ± 0.68 ) mg/L,hs-CRP (7.24±4.55)mg/L and ApoB(1.22±0.17)g/L in DN group were increased compared with DM group (all P<0.01).Serum levels of ApoA1 were decreased in DN group compared with DM group [(0.88±0.17) g/L vs.(1.02±0.17) g/L,P<0.01].The serum levels of LP (a) (r=0.487,P<0.05),Cys-C(r=0.55,P<0.05),hs-CRP(r=0.478,P<0.01) and ApoB(r=0.505,P<0.05) were positively correlated with urinary mAlb in T2DM patients,while ApoA1 was negtively related with mAIb(r=-0.52,P<0.05).Conclusions The serum LP (a),Cys C,Apo and hsCRP could be sensitive markers of early renal impairment,and their combinatorial measurement offers more value in patients with T2DM.