CAJ | 학술논문

目的检测CD147、Galeetin-3及微血管密度(MVD)在侵袭性和非侵袭性垂体腺瘤中的表达,以探讨其与垂体腺瘤MRI侵袭特征的关系.方法对34例垂体腺瘤患者术前行MRI检查,术后收集标本应用免疫组化sP法检测垂体腺瘤标本中CD147、Galeetin-3及MVD的表达,分析MRI侵袭性表现与CD147、Galecfin-3及MVD表达之间的关系.结果在垂体腺瘤相关MRI侵袭征象中,肿瘤超过外切线、海绵窦段颈内动脉被肿瘤包绕>50%、蝶窦侵犯、肿瘤形态不规则及双侧颈内动脉的不对称性均与CD147及Galectin-3的表达有关(P<0.05),肿瘤囊变坏死及瘤卒中与CD147及Galectin-3表达无关(P>0.05).结论 CD147及Galectin-3的高表达与垂体腺瘤MRI侵袭特征密切相关,CD147和Galectin-3可以作为垂体腺瘤侵袭性的分子标记物.
목적 검측CD147、Galeetin-3급미혈관밀도(MVD)재침습성화비침습성수체선류중적표체,이탐토기여수체선류MRI침습특정적관계.방법 대34례수체선류환자술전행MRI검사,술후수집표본응용면역조화sP법검측수체선류표본중CD147、Galeetin-3급MVD적표체,분석MRI침습성표현여CD147、Galecfin-3급MVD표체지간적관계.결과 재수체선류상관MRI침습정상중,종류초과외절선、해면두단경내동맥피종류포요>50%、접두침범、종류형태불규칙급쌍측경내동맥적불대칭성균여CD147급Galectin-3적표체유관(P<0.05),종류낭변배사급류졸중여CD147급Galectin-3표체무관(P>0.05).결론 CD147급Galectin-3적고표체여수체선류MRI침습특정밀절상관,CD147화Galectin-3가이작위수체선류침습성적분자표기물.
Objective To investigate the expression of CD147, Galeetin-3 and microvessel density(MVD) in invasive and non-invasive pituitary adenomas, and to evaluate the relationship between MRI invasive features and expression of CD147, Galectin-3 and MVD in pituitary adenomas. Methods MRI was performed preoperatively in 34 patients with histologically verified pituitary adenomas. The expression of CD147, Galectin-3 and MVD were determined by using immunohistochemical SP method in all patients. The correlation between MRI features and expression of CD147, Galectin-3 and MVD were studied between invasive and non-invasive pituitary adenomas. Results Among MRI invasive features, adenoma crossing the lateral line of internal carotid artery ( ICA ), the encasement of ICA by tumors over 50%, sphenoidal sinus invasion, irregular tumor shape and bilateral ICA asymmetry were correlated with increased expression of CD147 and Galectin-3 ( P<0.05 ), but tumor cystic necrosis and tumor apoplexy were not correlated with the expression of CD147 and Galectin-3 ( P>0.05 ). Conclusion The increased expression of CD147 and Galectin-3 may be related to MRI invasive features, CD147 and Galectin-3 are two molecular markers for assessing the invasion of pituitary adenomas. MRI is very useful in determining the invasive scope and extent of pituitary adenomas.