北京中医药大学学报
北京中醫藥大學學報
북경중의약대학학보
JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
2009年
9期
611-613
,共3页
张晓梅%姜良铎%张伟%吴建军%鲁香凤
張曉梅%薑良鐸%張偉%吳建軍%魯香鳳
장효매%강량탁%장위%오건군%로향봉
肺纤方%肺间质纤维化%血小板衍生因子%内皮素%血栓素%大鼠
肺纖方%肺間質纖維化%血小闆衍生因子%內皮素%血栓素%大鼠
폐섬방%폐간질섬유화%혈소판연생인자%내피소%혈전소%대서
Feixian Formula%pulmonary interstitial fibrosis%platelet-derived growth factor%endothelin%thromboxane%rats
目的 探讨活血化瘀药物肺纤方抑制肺间质纤维化大鼠肺组织血管生成和重构的作用机理.方法 气管内注入博莱霉素制造大鼠肺纤维化模型,造模后14、28、45 d检测模型组、假手术组、肺纤方组、泼尼松组血清中的血小板衍生因子、内皮素、血栓素.结果 肺纤方能够显著降低血清中的血小板衍生因子、内皮素、血栓素.结论 肺纤方抗肺纤维化的作用机理,可能与抑制肺间质纤维化大鼠肺组织血管生成和重构有关.
目的 探討活血化瘀藥物肺纖方抑製肺間質纖維化大鼠肺組織血管生成和重構的作用機理.方法 氣管內註入博萊黴素製造大鼠肺纖維化模型,造模後14、28、45 d檢測模型組、假手術組、肺纖方組、潑尼鬆組血清中的血小闆衍生因子、內皮素、血栓素.結果 肺纖方能夠顯著降低血清中的血小闆衍生因子、內皮素、血栓素.結論 肺纖方抗肺纖維化的作用機理,可能與抑製肺間質纖維化大鼠肺組織血管生成和重構有關.
목적 탐토활혈화어약물폐섬방억제폐간질섬유화대서폐조직혈관생성화중구적작용궤리.방법 기관내주입박래매소제조대서폐섬유화모형,조모후14、28、45 d검측모형조、가수술조、폐섬방조、발니송조혈청중적혈소판연생인자、내피소、혈전소.결과 폐섬방능구현저강저혈청중적혈소판연생인자、내피소、혈전소.결론 폐섬방항폐섬유화적작용궤리,가능여억제폐간질섬유화대서폐조직혈관생성화중구유관.
Objective To investigate the effect of Feixian Formula (with effects of activating blood circulation and resolving stasis), and mechanism of inhibiting lung vascular genesis and remodeling in rats with pulmonary interstitial fibrosis. Method The rat model of pulmonary interstitial fibrosis was established with intratracheal injection of bleomycin. On the 14th, 28th and 45th day after the establishment of the model the serum levels of platelet-derived growth factor (PDGF), endothelin (ET) and thromboxane (TXB-2) were detected in the model group, sham-operation group, Feixian Formula group and prednisone group respectively. Result Feixian Formula decreased significantly the serum levels of PDGF, ET and TXB-2. Conclusion The mechanism of antifibrosis of Feixian Formula may be related to that it can inhibit the lung vascular genesis and remodeling in rats with pulmonary interstitial fibrosis.
