CAJ | 학술논문

许多影响人类健康的重大疾病如高血压、哮喘和肥胖等都是复杂性状相关疾病.模式动物小鼠作为复杂性状研究的重要遗传资源,至今已有2900个数量性状基因座(QTL)在小鼠中被初步定位,然而国内对于小鼠复杂性状相天基因研究的报道并不多.本文埘近交系小鼠在复杂性状研究中的优势以及利用近交系小鼠进行QTL初步定位和精细定位的策略进行了综述,并重点介绍小鼠QTL克隆所面临的挑战,提出利用合作杂交计划和野生小鼠资源解决QTL基因研究费时费力且定位分辨率低等一系列瓶颈问题的新思路.
허다영향인류건강적중대질병여고혈압、효천화비반등도시복잡성상상관질병.모식동물소서작위복잡성상연구적중요유전자원,지금이유2900개수량성상기인좌(QTL)재소서중피초보정위,연이국내대우소서복잡성상상천기인연구적보도병불다.본문시근교계소서재복잡성상연구중적우세이급이용근교계소서진행QTL초보정위화정세정위적책략진행료종술,병중점개소소서QTL극륭소면림적도전,제출이용합작잡교계화화야생소서자원해결QTL기인연구비시비력차정위분변솔저등일계렬병경문제적신사로.
Most of human diseases such as hypertension, asthma and obesity are complex trait diseases that are inilunced by both gentic and environmental factors. The identification of molecular polymorhisms of genes responsible for complex traits is among the most important challenges in the post-genome era. Mouse models have extensively been used for complex trait studies and thousands of quantitative trait loci (QTLs) regulating various traits have been mapped in mice genome over the last two decades. However, there are few such researches performed in China and we hope to heat up researches of genetic dissection of complex traits with mice by reviewing how the positional cloning of QTLs with inbred mice is done.