CAJ | 학술논문

目的探讨静脉注射利多卡因对结直肠切除手术的影响.方法将60例择期行结直肠切除手术患者按随机数字表法分为两组,L组为利多卡因组,诱导期前静脉注射1%利多卡因1.5 mg/kg,随后以1.5 mg/(kg·h)的速度持续静脉输注至术后12 h;C组为0.9%氯化钠对照组,输注同量的0.9%氯化钠.记录术后疼痛视觉模拟量表(VAS)评分、吗啡的用量及术后肛门排气和第1次排便时间.结果 L组维持血流动力学稳定的呼气末七氟烷浓度明显低于C组(P<0.05).L组术中舒芬太尼用量为(17.5±3.8)μg,C组为(25.6±4.5)μg,两组比较差异有统计学意义(P<0.05).L组术后肛门排气时间、第1次排便时间及术后24、48 h吗啡用量[(23±6)h、(31±7)h、(32±6)mg、(58±7)mg]均低于C组[(28±7)h、(43±9)h、(46±8)mg、(71±10)mg](P<0.05).术后各时间点静息VAS评分两组比较差异无统计学意义;但活动和咳嗽时VAS评分L组低于C组(P<0.05).结论围手术期静脉注射小剂量利多卡因有利于结直肠切除手术后的康复.
목적 탐토정맥주사리다잡인대결직장절제수술적영향.방법 장60례택기행결직장절제수술환자안수궤수자표법분위량조,L조위리다잡인조,유도기전정맥주사1%리다잡인1.5 mg/kg,수후이1.5 mg/(kg·h)적속도지속정맥수주지술후12 h;C조위0.9%록화납대조조,수주동량적0.9%록화납.기록술후동통시각모의량표(VAS)평분、마배적용량급술후항문배기화제1차배편시간.결과 L조유지혈류동역학은정적호기말칠불완농도명현저우C조(P<0.05).L조술중서분태니용량위(17.5±3.8)μg,C조위(25.6±4.5)μg,량조비교차이유통계학의의(P<0.05).L조술후항문배기시간、제1차배편시간급술후24、48 h마배용량[(23±6)h、(31±7)h、(32±6)mg、(58±7)mg]균저우C조[(28±7)h、(43±9)h、(46±8)mg、(71±10)mg](P<0.05).술후각시간점정식VAS평분량조비교차이무통계학의의;단활동화해수시VAS평분L조저우C조(P<0.05).결론 위수술기정맥주사소제량리다잡인유리우결직장절제수술후적강복.
Objective To investigate the effects of intravenous infusion of lidocaine on colorectal resection.Methods Sixty patients undergoing colorectsl resection were randomly divided into group L [receiving intravenous infusion of 1%lidocaine,bolus injection of 1.5 mg/kg lldocaine at induction of anesthesia,followed by a continuous infusion of 1.5 mg/(kg·h)intraoperatively and for 12 h postoperatively]and group C(an equal volume of saline).Postoperative pain scores(VAS score)and morphine consumption were measured.Times of flatus and first defecation were recorded.Results The end expiration sevotturane concentration maintaining hemedynamics stable in group L was lower than that in group C(P<0.05).The dose of sulfentsnyl was(17.5±3.8)μg in group L,(25.6±4.5)μg in group C,there was significant difference between two groups(P<0.05).The times of flatus first,defecation and morphine conaumption at 24 and 48 h after operation in group L were lower than those in group C[(23±6)h vs(28±7)h,(31±7)h vs(43±9)h,(32±6)mg vs(46±8)nag and(58±7)mg vs(71±10)mg,P<0.05].There was no significant difference at resting VAS score,but there was significant difference at movement and cough VAS score between twp groups(P<0.05).Conclusion Perioperative administration of low doses of intravenous infusion of lidocaine reduces intraoperative anesthetic requirements and has a clinically relevant beneficial effect on postoperative recovery after colorectal resection.