CAJ | 학술논문

目的：观察参麦注射液联合低分子肝素钙治疗不稳定型心绞痛的临床疗效及安全性。方法120例不稳定型心绞痛患者在知情同意情况下按入院单双号随机分为观察组(60例)和对照组(60例)，对照组采用心绞痛常规治疗，观察组在对照组治疗的基础上给予参麦注射液联合低分子肝素钙治疗，观察比较两组治疗前后出血时间、凝血时间、凝血酶原时间、心电图变化及临床疗效。结果治疗2个疗程后，观察组有效52例、无效8例、有效率为86.7％，对照组分别为36例、24例、60.0％，两组有效率差异有统计学意义(x2 =9.19，P＜0.05)；两组治疗后出血时间、凝血时间、凝血酶原时间等较治疗前差异均无统计学意义(均P＞0.05)；观察组心电图疗效：有效53例、无效7例、有效率88.3％，对照组分别为39例、21例、65.0％，两组心电图疗效差异有统计学意义(x2 =8.83，P＜0.05)。结论参麦注射液联合低分子肝素钙治疗不稳定型心绞痛疗效显著，安全可靠。
목적：관찰삼맥주사액연합저분자간소개치료불은정형심교통적림상료효급안전성。방법120례불은정형심교통환자재지정동의정황하안입원단쌍호수궤분위관찰조(60례)화대조조(60례)，대조조채용심교통상규치료，관찰조재대조조치료적기출상급여삼맥주사액연합저분자간소개치료，관찰비교량조치료전후출혈시간、응혈시간、응혈매원시간、심전도변화급림상료효。결과치료2개료정후，관찰조유효52례、무효8례、유효솔위86.7％，대조조분별위36례、24례、60.0％，량조유효솔차이유통계학의의(x2 =9.19，P＜0.05)；량조치료후출혈시간、응혈시간、응혈매원시간등교치료전차이균무통계학의의(균P＞0.05)；관찰조심전도료효：유효53례、무효7례、유효솔88.3％，대조조분별위39례、21례、65.0％，량조심전도료효차이유통계학의의(x2 =8.83，P＜0.05)。결론삼맥주사액연합저분자간소개치료불은정형심교통료효현저，안전가고。
Objective To explore the effecf of Shenmai injection combined with low molecular weight heparin treatment of unstable angina with the clinical experience. Methods 120 patients with unstable angina pectoris as the research object,using control study ,patients were randomly divided into two groups( 60 cases)and control group (60). Control group with conventional therapy,the treatment group were given treatment on the basis of low molecular weight heparin calcium Shenmai joint treatment, two groups were compared before and after treatment by bleeding time,coagulation time,prothrombin time,and ECG changes,compared two groups. Results After 2 courses of treatment,52 cases was effective in observation group,the effective rate was 86.67％ ;36 cases was effective in the control group,the effective rate was 60.00％. The difference of effective rate between the two groups was statistically significant(x2 =9.19,P ＜0.05) ;The difference of bleeding time,coagulation time, prothrombin time between before and treatment were not statistically significant( all P ＞ 0.05 ), ECG,53 cases was effective in observation group, the effective rate was 88.33％ ,39 cases was effective in the control group, the effective rate was 65.00％. the difference of effective rate between the two groups was statistically significant( x2 =8.83 ,P ＜ 0. 05). Conclusion The addition of conventional therapy combined low molecular weight heparin Shenmai treatment of unstable angina was significant effect,safe and reliable,and worthy of clinical use.