中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2011年
2期
88-92
,共5页
张璐璐%郑洪波%宁玉萍%马崔%彭建玲
張璐璐%鄭洪波%寧玉萍%馬崔%彭建玲
장로로%정홍파%저옥평%마최%팽건령
抑郁%脑源性神经营养因子%基因%多态性,限制性片断长度%认知
抑鬱%腦源性神經營養因子%基因%多態性,限製性片斷長度%認知
억욱%뇌원성신경영양인자%기인%다태성,한제성편단장도%인지
Depression%Brain-derived neurotrophic factor%Genes%Polymorphism,restriction fragment length%Cognition
目的 探讨脑源性神经营养因子(BDNF)基因Va166Met多态性与重性抑郁障碍认知功能的关系.方法 以100例重性抑郁障碍患者(患者组)与100名健康志愿者(对照组)为研究对象,采用1组神经心理学检测评估认知功能,并检测BDNF基因多态性;分别按照总智商(FIQ)、威斯康星卡片分类测验改良版(M-WCST)分类数、正确数、持续错误数、河内塔测试(TOH)计划时间、执行时间及总分的测验成绩由好到差排序,将患者组分为组1(成绩前50例,认知功能较好的患者)和组2(成绩后50例,认知功能较差的患者),检测组1与组2 BDNF基因型频率分布.结果 (1)对照组:除数字广度外,其他神经心理学测验成绩在BDNF基因型间的差异均无统计学意义(P>0.05).(2)患者组:中国修订韦氏成人智力量表(WAIS-RC)FIQ[(102.1±11.5)分vs(92.5±10.2)分]、M-WCST分类数[(5.6±1.7)分vs(2.9±1.2)分]和正确数[(36.5±6.0)分vs(26.8±5.6)分]、TOH总分[(50.8±9.6)分vs(40.4±9.3)分]及各项测验成绩,连线测验(TMT)A耗时数和B耗时数的成绩在患者组Val/Val基因型均优于Met/Met基因型,差异有统计学意义(P均<0.01).(3)组1Met/Met基因型频率分布显著低于组2,差异均有统计学意义(P均<0.01);除FIQ和TOH执行时间外,其他各项组1 Val/Val基因型频率显著高于组2,差异有统计学意义(P均<0.05).结论 BDNF基因Va166Met多态性与重性抑郁障碍患者认知功能损害可能有关.
目的 探討腦源性神經營養因子(BDNF)基因Va166Met多態性與重性抑鬱障礙認知功能的關繫.方法 以100例重性抑鬱障礙患者(患者組)與100名健康誌願者(對照組)為研究對象,採用1組神經心理學檢測評估認知功能,併檢測BDNF基因多態性;分彆按照總智商(FIQ)、威斯康星卡片分類測驗改良版(M-WCST)分類數、正確數、持續錯誤數、河內塔測試(TOH)計劃時間、執行時間及總分的測驗成績由好到差排序,將患者組分為組1(成績前50例,認知功能較好的患者)和組2(成績後50例,認知功能較差的患者),檢測組1與組2 BDNF基因型頻率分佈.結果 (1)對照組:除數字廣度外,其他神經心理學測驗成績在BDNF基因型間的差異均無統計學意義(P>0.05).(2)患者組:中國脩訂韋氏成人智力量錶(WAIS-RC)FIQ[(102.1±11.5)分vs(92.5±10.2)分]、M-WCST分類數[(5.6±1.7)分vs(2.9±1.2)分]和正確數[(36.5±6.0)分vs(26.8±5.6)分]、TOH總分[(50.8±9.6)分vs(40.4±9.3)分]及各項測驗成績,連線測驗(TMT)A耗時數和B耗時數的成績在患者組Val/Val基因型均優于Met/Met基因型,差異有統計學意義(P均<0.01).(3)組1Met/Met基因型頻率分佈顯著低于組2,差異均有統計學意義(P均<0.01);除FIQ和TOH執行時間外,其他各項組1 Val/Val基因型頻率顯著高于組2,差異有統計學意義(P均<0.05).結論 BDNF基因Va166Met多態性與重性抑鬱障礙患者認知功能損害可能有關.
목적 탐토뇌원성신경영양인자(BDNF)기인Va166Met다태성여중성억욱장애인지공능적관계.방법 이100례중성억욱장애환자(환자조)여100명건강지원자(대조조)위연구대상,채용1조신경심이학검측평고인지공능,병검측BDNF기인다태성;분별안조총지상(FIQ)、위사강성잡편분류측험개량판(M-WCST)분류수、정학수、지속착오수、하내탑측시(TOH)계화시간、집행시간급총분적측험성적유호도차배서,장환자조분위조1(성적전50례,인지공능교호적환자)화조2(성적후50례,인지공능교차적환자),검측조1여조2 BDNF기인형빈솔분포.결과 (1)대조조:제수자엄도외,기타신경심이학측험성적재BDNF기인형간적차이균무통계학의의(P>0.05).(2)환자조:중국수정위씨성인지역량표(WAIS-RC)FIQ[(102.1±11.5)분vs(92.5±10.2)분]、M-WCST분류수[(5.6±1.7)분vs(2.9±1.2)분]화정학수[(36.5±6.0)분vs(26.8±5.6)분]、TOH총분[(50.8±9.6)분vs(40.4±9.3)분]급각항측험성적,련선측험(TMT)A모시수화B모시수적성적재환자조Val/Val기인형균우우Met/Met기인형,차이유통계학의의(P균<0.01).(3)조1Met/Met기인형빈솔분포현저저우조2,차이균유통계학의의(P균<0.01);제FIQ화TOH집행시간외,기타각항조1 Val/Val기인형빈솔현저고우조2,차이유통계학의의(P균<0.05).결론 BDNF기인Va166Met다태성여중성억욱장애환자인지공능손해가능유관.
objective To investigate relationship between brain-derived neurotrophic factor (BDNF)gene Va166Met polymorphism and cognitive function in patients with major depressive disorder.Methods One hundred patients with major depressive disorder and 100 healthy volunteers were included.The cognitive function was assessed by a series of neuropsychology tests,and BDNF gene polymorphism was detected.Results (1)In control group,the achievements of all neuropsychology tests except for digit span were not significantly different among ones with different BDNF genotypes(P>0.05).(2)In patient group,the achievements of neuropsychology tests such as WAIS-RC(102.1±1 1.5 vs.92.5±10.2),M-WCST(5.6±1.7 vs.2.9±1.2,36.5±6.0 vs.26.8±5.6),TOH(50.8±9.6 vs.40.4±9.3),time for TMT-A and TMT-B,were significantly better in ones with Val/Val genotype than in ones with Met/Met genotype(P≤0.01).(3)The Val/Val genotype frequency in patients with better cognitive function was higher than that in patients with worse cognitive function,while Met/Met genotype frequency was in the opposite direction(P<0.05 or P<0.01).Conclusion The BDNF gene Va166Met polymorphism is possibly correlated with impairment of cognitive function in patients with major depressive disorder.
