CAJ | 학술논문

目的了解致病性A组链球菌(GAS)在广东新兴地区的病种分布及其耐药情况,以便指导临床用药.方法 2007年1月至2009年6月间,采集新兴地区学龄期儿童咽拭子、脓液等标本2063例,共分离出致病性GAS菌株85例,药物敏感性试验用含5%去纤维羊血的M-H琼脂培养基.按K-B纸片扩散法进行.结果 85株致病性GAS菌株中急性咽炎36株,化脓性扁桃腺炎25株,急性风湿热5株,急性肾小球肾炎6株,银屑病4株,其他病种9株;对红霉素等大环内酯为耐药达77.65%以上,除克林霉素外,GAS对其他类抗生素耐药率与大环内酯类比较(P＜0.05),差异有显著性;急性风湿热与化脓性扁桃腺炎、急性咽炎病例中的GAS对头孢菌类耐药率比较(P＜0.05),差异有显著性.结论本地区致病性GAS分布较广泛,治疗或预防GAS感染仍宜首选青霉素类或头孢菌素类.
목적 료해치병성A조련구균(GAS)재엄동신흥지구적병충분포급기내약정황,이편지도림상용약.방법 2007년1월지2009년6월간,채집신흥지구학령기인동인식자、농액등표본2063례,공분리출치병성GAS균주85례,약물민감성시험용함5%거섬유양혈적M-H경지배양기.안K-B지편확산법진행.결과 85주치병성GAS균주중급성인염36주,화농성편도선염25주,급성풍습열5주,급성신소구신염6주,은설병4주,기타병충9주;대홍매소등대배내지위내약체77.65%이상,제극림매소외,GAS대기타류항생소내약솔여대배내지류비교(P＜0.05),차이유현저성;급성풍습열여화농성편도선염、급성인염병례중적GAS대두포균류내약솔비교(P＜0.05),차이유현저성.결론 본지구치병성GAS분포교엄범,치료혹예방GAS감염잉의수선청매소류혹두포균소류.
Objective To investigate clinical diseases distribution and drug re-sistance of the pathogenicity of group A Streptococcus (GAS) from Xinxing area in Guangdong and guide the clinical use.Methods 85 GAS isolates were collected from 2063 cases of school-age children's throat swab,pus and other specimens in Xinxing area during January 2007 to June 2009.Drug sensitivity tests were evaluated by the K-B disk diffusion method containing 5% fiber blood to the M-H agar.Resusts Pathogenicity of 85 GAS acute pharyngitis 36,suppurative tonsillitis 25,acute rheumatic fever 5,acute glomerulonephritis 6,psoriasis 4,Other diseases 9.The resistance rates to erythromycin and other macrolides was more than 77.65 percent,Except Clindamycin,GAS resistant to other antibiotics compared with the macrolides (P＜0.05),There was significant difference.Acute rheumatic fever and suppurative tonsillitis,acute pharyngitis cases of GAS resistant to the cephalosporins rate (P＜0.05),There was significant difference.Conclusions GAS pathogenicity is wider distribution in this area,Penicillins and cephalosporins should still be the first choice for the treatment or prevention of GAS infection.