CAJ | 학술논문

目的观察吸烟对早期糖尿病肾病静息能量消耗(REE)的影响及与氧化应激和炎症反应之间的关系.方法对31例吸烟和40例非吸烟的早期糖尿病肾病患者的一般情况、临床特征、REE、REE与去脂组织(FFM)的比值、氧化应激及炎症反应标志物进行比较分析.结果吸烟组的REE/FFM比非吸烟组显著增高15.96%(P=0.001).相关分析提示,REE/FFM的增高与吸烟有关(t=0.395,P=0.001).氧化应激标志物丙二醛(MDA)、超氧化物歧化酶(SOD)和炎症反应标志物高敏C反应蛋白(hs-CRP)两组间差异有统计学意义(P＜0.05),脂联素、TNFα组间差异无统计学意义(P＞0.05),REE/FFM的增高与MDA、SOD、hs-CRP、脂联素、TNFα均不相关(P＞0.05).结论吸烟可导致早期2型糖尿病肾病患者REE增加,引起氧化应激和炎症反应,但REE增高与氧化应激和炎症反应无关.
목적 관찰흡연대조기당뇨병신병정식능량소모(REE)적영향급여양화응격화염증반응지간적관계.방법 대31례흡연화40례비흡연적조기당뇨병신병환자적일반정황、림상특정、REE、REE여거지조직(FFM)적비치、양화응격급염증반응표지물진행비교분석.결과 흡연조적REE/FFM비비흡연조현저증고15.96%(P=0.001).상관분석제시,REE/FFM적증고여흡연유관(t=0.395,P=0.001).양화응격표지물병이철(MDA)、초양화물기화매(SOD)화염증반응표지물고민C반응단백(hs-CRP)량조간차이유통계학의의(P＜0.05),지련소、TNFα조간차이무통계학의의(P＞0.05),REE/FFM적증고여MDA、SOD、hs-CRP、지련소、TNFα균불상관(P＞0.05).결론 흡연가도치조기2형당뇨병신병환자REE증가,인기양화응격화염증반응,단REE증고여양화응격화염증반응무관.
Objective To study the effect of smoking on resting energy expenditure ( REE ) and the relationships among REE, smoking , inflammation and oxidative stress in patients with diabetic kidney disease. Methods A case control study of 31 smokers and 40 non-smokers with early stage of diabetic kidney disease( stage Ⅲ ) were performed to evaluate the chronic effect of smoking on REE. REE/fat free mass( FFM ), biomarkers of oxidative stress malondialdehyde ( MDA ), superoxide dismutase ( SOD ) and inflammation high-sensitivity C-reactive protein (hs-CRP), adiponectin, TNFα were also measured in these subjects. Data were analyzed by Pearson correlation analysis. Results Compared with non-smokers, REE/FFM in smokers group was significantly increased by 15.96% ( P =0.001 ). Pearson analysis showed that smoking was significantly correlated with REE/FFM ( t = 0.395, P = 0.001 ). There were significantly different between smokers and non-smokers in MDA, SOD and hs-CRP ( P＜0.05 ). But no difference between two groups in adiponectin and TNFα ( P ＞ 0.05 ). No significant relationships between REE/FFM and MDA, SOD, hs-CRP, adiponectin, TNFα was found ( P ＞ 0.05 ). Conclusion Chronic smoking can lead to increased REE, arouse oxidative stress and inflammatory in patients with early stage of diabetic kidney disease. However, there is no relationship between increased REE due to smoking and oxidative stress and inflammatory.