CAJ | 학술논문

目的探讨磷酸化哺乳动物雷帕霉素靶蛋白(p-mTOR)在良恶性子宫内膜病变组织中的表达情况.方法应用免疫组化SP法检测45例子宫内膜样腺癌、7例子宫内膜非典型增生、6例增殖期子宫内膜组织中p-mTOR的表达情况.结果 p-mTOR主要分布于细胞质,在增殖期子宫内膜中呈弱阳性表达或阴性表达,蛋白颗粒密度为2.36±0.76;在子宫内膜非典型增生和子宫内膜样腺癌中高表达,蛋白颗粒密度分别为6.21±1.19、15.82±2.64,三者间比较差异有统计学意义(F=11.37,P＜0.05).在子宫内膜样腺癌组织中,不同组织学分级p-mTOR表达差异有统计学意义(F=8.27,P＜0.05),但不同病理分期p-mTOR表达差异无统计学意义(P＞0.05).结论 p-mTOR可能参与了子宫内膜癌的发生和发展过程.
목적 탐토린산화포유동물뢰파매소파단백(p-mTOR)재량악성자궁내막병변조직중적표체정황.방법 응용면역조화SP법검측45례자궁내막양선암、7례자궁내막비전형증생、6례증식기자궁내막조직중p-mTOR적표체정황.결과 p-mTOR주요분포우세포질,재증식기자궁내막중정약양성표체혹음성표체,단백과립밀도위2.36±0.76;재자궁내막비전형증생화자궁내막양선암중고표체,단백과립밀도분별위6.21±1.19、15.82±2.64,삼자간비교차이유통계학의의(F=11.37,P＜0.05).재자궁내막양선암조직중,불동조직학분급p-mTOR표체차이유통계학의의(F=8.27,P＜0.05),단불동병리분기p-mTOR표체차이무통계학의의(P＞0.05).결론 p-mTOR가능삼여료자궁내막암적발생화발전과정.
Objective To investigate the expression of phosphorylation-mammalian target of rapamycin (p-mTOR) in endometrial carcinoma. Methods The expressions of p-mTOR protein in tissues from 45 cases of endometrial adenocarcinoma, 7 endometrial atypical hyperplasia, and 6 normal endometrium were detected by immunohistochemistry SP method. Results The expression of p-mTOR protein maily restricted to cytoplasm. Compared with normal endometrium, the expression of p-mTOR protein in the cases of endometrial atypical hyperplasia and endometrial adenocarcinoma was significantly up-regulation(2.36 ± 0.76vs 6.21 ± 1.19, 15.82 ± 2.64)( F = 11.37, P ＜ 0.05 ). There was significant difference of p-mTOR protein in different histology class in endometrial adenocarcinoma (F = 8.27, P ＜ 0.05), but there was no significant difference of p-mTOR protein in different pathological grade in endometrial adenocarcinoma (P ＞0.05).Conclusion The expression of p-mTOR protein may participate in the occurrence and development of endometrial carcinoma.