中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2009年
9期
935-938
,共4页
王晓晨%徐岩%程自平%许邦龙%陈斌%陈旭华%伍梦佐%林先和%朱润硕
王曉晨%徐巖%程自平%許邦龍%陳斌%陳旭華%伍夢佐%林先和%硃潤碩
왕효신%서암%정자평%허방룡%진빈%진욱화%오몽좌%림선화%주윤석
白细胞介素-10%睾酮%冠心病
白細胞介素-10%睪酮%冠心病
백세포개소-10%고동%관심병
Interleukin-10%Testosterone%Coronary heart disease
目的 研究血清白细胞介素-10(IL-10)及睾酮与冠心病(CHD)的关系.方法 依据冠状动脉造影结果 将387例患者分为CHD组239例及对照组148例,并根据冠状动脉病变支数、积分和临床病情(稳定型冠心病、不稳定型心绞痛和急性心肌梗死)将CHD组分为不同亚组;ELISA法检测血清IL-10和睾酮浓度;采用Logistic回归及偏相关方法 分析IL-10及睾酮与CHD的关系.结果 CHD组血清IL-10水平显著低于对照组[(39.08±14.22)ng/L与(49.27±24.67)ng/L,P<0.001].IL-10水平及与冠状动脉病变支数,积分和临床病情呈负相关[rs(支数)=-0.25,P<0.001;rs(积分)=-0.25,P<0.05;rs(病情)=-0.25,P<0.001].血清睾酮水平在CHD组和对照组之间差异无统计学意义(P>0.05),相关分析也未发现睾酮与CHD相关.多因素逐步Logistic回归分析提示吸烟(OR 3.79,95%可信区间2.09～6.84,P<0.01)、糖尿病(OR 2.48,95%可信区间1.05～5.88,P<0.05)、ApoB(OR 14.3,95%可信区间4.29～46.61,P<0.01)和IL-10(OR 0.74,95%可信区间0.57～0.89,P<0.01)进入模型.结论 血清IL-10水平不仅与CHD的发生相关,而且与其严重程度相关,IL-10是CHD的独立保护因素.血清睾酮水平可能与CHD无关.
目的 研究血清白細胞介素-10(IL-10)及睪酮與冠心病(CHD)的關繫.方法 依據冠狀動脈造影結果 將387例患者分為CHD組239例及對照組148例,併根據冠狀動脈病變支數、積分和臨床病情(穩定型冠心病、不穩定型心絞痛和急性心肌梗死)將CHD組分為不同亞組;ELISA法檢測血清IL-10和睪酮濃度;採用Logistic迴歸及偏相關方法 分析IL-10及睪酮與CHD的關繫.結果 CHD組血清IL-10水平顯著低于對照組[(39.08±14.22)ng/L與(49.27±24.67)ng/L,P<0.001].IL-10水平及與冠狀動脈病變支數,積分和臨床病情呈負相關[rs(支數)=-0.25,P<0.001;rs(積分)=-0.25,P<0.05;rs(病情)=-0.25,P<0.001].血清睪酮水平在CHD組和對照組之間差異無統計學意義(P>0.05),相關分析也未髮現睪酮與CHD相關.多因素逐步Logistic迴歸分析提示吸煙(OR 3.79,95%可信區間2.09～6.84,P<0.01)、糖尿病(OR 2.48,95%可信區間1.05～5.88,P<0.05)、ApoB(OR 14.3,95%可信區間4.29～46.61,P<0.01)和IL-10(OR 0.74,95%可信區間0.57～0.89,P<0.01)進入模型.結論 血清IL-10水平不僅與CHD的髮生相關,而且與其嚴重程度相關,IL-10是CHD的獨立保護因素.血清睪酮水平可能與CHD無關.
목적 연구혈청백세포개소-10(IL-10)급고동여관심병(CHD)적관계.방법 의거관상동맥조영결과 장387례환자분위CHD조239례급대조조148례,병근거관상동맥병변지수、적분화림상병정(은정형관심병、불은정형심교통화급성심기경사)장CHD조분위불동아조;ELISA법검측혈청IL-10화고동농도;채용Logistic회귀급편상관방법 분석IL-10급고동여CHD적관계.결과 CHD조혈청IL-10수평현저저우대조조[(39.08±14.22)ng/L여(49.27±24.67)ng/L,P<0.001].IL-10수평급여관상동맥병변지수,적분화림상병정정부상관[rs(지수)=-0.25,P<0.001;rs(적분)=-0.25,P<0.05;rs(병정)=-0.25,P<0.001].혈청고동수평재CHD조화대조조지간차이무통계학의의(P>0.05),상관분석야미발현고동여CHD상관.다인소축보Logistic회귀분석제시흡연(OR 3.79,95%가신구간2.09～6.84,P<0.01)、당뇨병(OR 2.48,95%가신구간1.05～5.88,P<0.05)、ApoB(OR 14.3,95%가신구간4.29～46.61,P<0.01)화IL-10(OR 0.74,95%가신구간0.57～0.89,P<0.01)진입모형.결론 혈청IL-10수평불부여CHD적발생상관,이차여기엄중정도상관,IL-10시CHD적독립보호인소.혈청고동수평가능여CHD무관.
Objective To evaluate the correlation between seram interleukin-10 (IL-10) and testosterone with coronary heart disease (CHD). Methods 387 patients were divided into CHD group (n = 239) and control group ( n = 148 ) according to the results of coronary angiography. CHD patients were divided into subgroups accord-ing to the numbers, Gensini score of lesions in the coronary arteries and clinical severity ( statue of stable coronary artery disease, unstable angina or acute myocardial infarction). Serum IL-10 and testosterone levels were measured by ELASA. Logistic regression and partial correlation were used to evaluate the correlation of serum IL-10 and testoster-one with CHD. Results IL-10 was significantly lower in the CHD group than in the control group[ (39.08 ± 14.22) ng/L vs (49.27 ± 24.67)ng/L, P < 0. 001 ]. The partial correlation analysis results in subgroups showed that the correlation coefficient of IL-10 with number of lesions,gensini score and clinical severity of CHD was - 0.25, P < 0.001, -0.25 ,P <0.05 and -0.25 ,P <0.001 ,respectively. Serum testosterone had no difference in control group and CHD group (P >0.05 ). Logistic regression analysis found that only smoking (OR = 3.79,95% CI 2.09～ 6.84,P<0.01) ,diabetes mellitus (OR =2.48,95% CI 1.05 ～5.88,P <0. 05) ,apoB ( OR = 14.3,95% CI 4.29～46.61 ,P <0.01 ) and IL-10 ( OR =0.74,95%, CI 0.57～0.89 ,P <0.01 ) entered the model. Conclusions Serum IL-10 is not only significantly correlated with CHD but also with its severity. IL-10 is an independent pro-tective factor for CHD.
