HAG预激方案治疗高危骨髓增生异常综合征的多中心观察
HAG예격방안치료고위골수증생이상종합정적다중심관찰
Clinical efficacies and safety of HAG regimen for patients with high-risk myelodysplastic syndromes:a multicentre study
  • 万方数据
    中华医学杂志 중화의학잡지
    National Medical Journal of China
    2012年 10期 689-691 ,共3页

    刘红%何广胜%吴德沛%孙爱宁%邵宗鸿%钱思轩%肖志坚%马军%王树叶%许小平%刘霆%金洁%陈智超%方美云%陈宝安%许兰平%沈志祥%阮长耿

    류홍%하엄성%오덕패%손애저%소종홍%전사헌%초지견%마군%왕수협%허소평%류정%금길%진지초%방미운%진보안%허란평%침지상%원장경

    骨髓增生异常综合征%缓解诱导%治疗效果%预激治疗 骨髓增生異常綜閤徵%緩解誘導%治療效果%預激治療
    골수증생이상종합정%완해유도%치료효과%예격치료
    Myelodysplastic syndromes%Remission induction%Treatment outcome%Primingtherapy
    目的 评价HAG方案(高三尖杉酯碱+阿糖胞苷+粒细胞集落刺激因子)治疗高危骨髓增生异常综合征(MDS)的疗效和安全性.方法 回顾性分析2008-2010年14家医院97例高危MDS患者进行HAG预激方案诱导缓解治疗的疗效.结果 总完全缓解率为52.3％ (45/86),总有效率为66.3％(57/86).早期病死率为9.3％ (9/97).年龄≥60岁的患者与年龄＜60岁的患者完全缓解率及总有效率差异均无统计学意义(均P＞0.05).按染色体核型判断预后,预后好、预后中度和预后差的患者的诱导治疗总有效率分别为29/34、9/12和6/13,预后好的治疗总有效率高于预后差的(P=0.038).不良反应主要为感染.结论 HAG方案治疗高危MDS有较高的完全缓解率和总有效率.
    목적 평개HAG방안(고삼첨삼지감+아당포감+립세포집락자격인자)치료고위골수증생이상종합정(MDS)적료효화안전성.방법 회고성분석2008-2010년14가의원97례고위MDS환자진행HAG예격방안유도완해치료적료효.결과 총완전완해솔위52.3％ (45/86),총유효솔위66.3％(57/86).조기병사솔위9.3％ (9/97).년령≥60세적환자여년령＜60세적환자완전완해솔급총유효솔차이균무통계학의의(균P＞0.05).안염색체핵형판단예후,예후호、예후중도화예후차적환자적유도치료총유효솔분별위29/34、9/12화6/13,예후호적치료총유효솔고우예후차적(P=0.038).불량반응주요위감염.결론 HAG방안치료고위MDS유교고적완전완해솔화총유효솔.
    Objective To evaluate the efficacies and toxicity of HAG ( HHT + Ara-C + G-CSF)regimen in patients with high-risk myelodysplastic syndromes(MDS).Methods A total of 97 patients with high-risk MDS received HAG regimen as the induction therapy.Results The comp山ete remission (CR) rate of all the patients was 52.3％ (45/86).The overall response (OR) rate was 66.3％ (57/86).The early mortality rate was 9.3％ (9/97).There was no significant difference in CR rate and OR rate between the patients aged≥ 60 and those ＜60.The OR rate was 29/34,9/12 and 6/13 in patients with favorable karyotype,intermediate karyotype and unfavorable karyotype respectively. The OR rate was higher in patients with favorable karyotype than those with unfavorable karyotype ( P =0.038 ).The major adverse effect was infection.Conclusion HAG regimen provides higher CR rate and OR rate for patients with highrisk MDS.
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