中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2011年
4期
567-570,封3
,共5页
胃癌%CD11c%黏附分子%免疫组织化学
胃癌%CD11c%黏附分子%免疫組織化學
위암%CD11c%점부분자%면역조직화학
Gastric carcinoma%CD11 c%Adhesion molecules%Immunohistochemical
目的 探讨黏附分子家族的成员CD11c在胃癌组织中的表达及其与预后的关系.方法 采用免疫组织化学染色法检测125例胃癌患者癌组织CD11c的表达.结果 CD11c在胃癌中的表达高于胃炎和胃息肉组织.CD11c与患者性别、年龄、病理分级、胃癌部位无关(P＞0.05);与肿瘤大小、浸润深度、淋巴结转移、组织类型、复发和TNM分期明显相关.肿瘤直径＜5 cm组CD11c的表达水平(12.4±6.8)高于肿瘤直径≥5 cm组(7.7±4.6),差异有统计学意义(t=3.98,P＜0.01).浸润深度与CD11c表达水平显著关联,未侵入肌层组胃癌的CD11c表达水平(15.4±8.5)显著高于侵入肌层组(9.5±5.6),差异有统计学意义(t=3.1,P＜0.05).淋巴结转移与CD11c表达水平显著关联,未有淋巴结转移的CD11c表达水平(15.3±6.6)显著高于淋巴结转移组(8.6±5.1),差异有统计学意义(t=5.44,P＜0.01).未复发组的CD11c表达水平(12.3±7.4)高于复发组(9.0±5.3),差异有统计学意义(t=2.90,P＜0.01).分化型组的CD11c表达水平(9.3±5.3)低于低分化型组(12.6±7.8),差异有统计学意义(t=2.68,P＜0.01).CD11c表达随肿瘤临床分期的递增而降低,各组间差异有统计学意义(P＜0.01).多因素COX模型分析,在调整了性别、年龄、肿瘤大小、是否侵及深肌层、分化程度后,与CD11c细胞低表达组比较,高表达组有降低胃癌死亡风险的趋势(RR=0.51,95%CI=0.22～1.16).结论 CD11c表达与胃癌预后有关,可以作为反映患者免疫状态和预后的指标之一.
目的 探討黏附分子傢族的成員CD11c在胃癌組織中的錶達及其與預後的關繫.方法 採用免疫組織化學染色法檢測125例胃癌患者癌組織CD11c的錶達.結果 CD11c在胃癌中的錶達高于胃炎和胃息肉組織.CD11c與患者性彆、年齡、病理分級、胃癌部位無關(P＞0.05);與腫瘤大小、浸潤深度、淋巴結轉移、組織類型、複髮和TNM分期明顯相關.腫瘤直徑＜5 cm組CD11c的錶達水平(12.4±6.8)高于腫瘤直徑≥5 cm組(7.7±4.6),差異有統計學意義(t=3.98,P＜0.01).浸潤深度與CD11c錶達水平顯著關聯,未侵入肌層組胃癌的CD11c錶達水平(15.4±8.5)顯著高于侵入肌層組(9.5±5.6),差異有統計學意義(t=3.1,P＜0.05).淋巴結轉移與CD11c錶達水平顯著關聯,未有淋巴結轉移的CD11c錶達水平(15.3±6.6)顯著高于淋巴結轉移組(8.6±5.1),差異有統計學意義(t=5.44,P＜0.01).未複髮組的CD11c錶達水平(12.3±7.4)高于複髮組(9.0±5.3),差異有統計學意義(t=2.90,P＜0.01).分化型組的CD11c錶達水平(9.3±5.3)低于低分化型組(12.6±7.8),差異有統計學意義(t=2.68,P＜0.01).CD11c錶達隨腫瘤臨床分期的遞增而降低,各組間差異有統計學意義(P＜0.01).多因素COX模型分析,在調整瞭性彆、年齡、腫瘤大小、是否侵及深肌層、分化程度後,與CD11c細胞低錶達組比較,高錶達組有降低胃癌死亡風險的趨勢(RR=0.51,95%CI=0.22～1.16).結論 CD11c錶達與胃癌預後有關,可以作為反映患者免疫狀態和預後的指標之一.
목적 탐토점부분자가족적성원CD11c재위암조직중적표체급기여예후적관계.방법 채용면역조직화학염색법검측125례위암환자암조직CD11c적표체.결과 CD11c재위암중적표체고우위염화위식육조직.CD11c여환자성별、년령、병리분급、위암부위무관(P＞0.05);여종류대소、침윤심도、림파결전이、조직류형、복발화TNM분기명현상관.종류직경＜5 cm조CD11c적표체수평(12.4±6.8)고우종류직경≥5 cm조(7.7±4.6),차이유통계학의의(t=3.98,P＜0.01).침윤심도여CD11c표체수평현저관련,미침입기층조위암적CD11c표체수평(15.4±8.5)현저고우침입기층조(9.5±5.6),차이유통계학의의(t=3.1,P＜0.05).림파결전이여CD11c표체수평현저관련,미유림파결전이적CD11c표체수평(15.3±6.6)현저고우림파결전이조(8.6±5.1),차이유통계학의의(t=5.44,P＜0.01).미복발조적CD11c표체수평(12.3±7.4)고우복발조(9.0±5.3),차이유통계학의의(t=2.90,P＜0.01).분화형조적CD11c표체수평(9.3±5.3)저우저분화형조(12.6±7.8),차이유통계학의의(t=2.68,P＜0.01).CD11c표체수종류림상분기적체증이강저,각조간차이유통계학의의(P＜0.01).다인소COX모형분석,재조정료성별、년령、종류대소、시부침급심기층、분화정도후,여CD11c세포저표체조비교,고표체조유강저위암사망풍험적추세(RR=0.51,95%CI=0.22～1.16).결론 CD11c표체여위암예후유관,가이작위반영환자면역상태화예후적지표지일.
Objectiye To investigate the expression of CD11c in gastric carcinoma and the clinical significance. Methods The expression of CD11 c in gastric carcinoma, gastritis tissue and gastric polyp was detected by using immunohistochemical assay. Results The expression level of CD11c in gastric carcinoma was higher than that in gastritis tissue and gastric polyp. There was no significant difference in the CD11 c expression among gender, age, pathological grade, primary area (P ＞ 0. 05 ). There was significant difference in the CD11c expression among tumor size, invasive depth, lymph node metastasis, histological type, recurrence and clinical stage. The expression of CD11c in tumor size ＜5 cm group ( 12.4 ±6. 8 ) was higher than that in tumor size ≥ 5 cm group (7.7 ± 4. 6), ( t = 3.98, P ＜ 0. 01 ). The expression of CD11c in non-invasion group ( 15.4 ± 8.5 ) was obviously higher than that in invasion group (9.5 ±5.6), ( t = 3.1 ,P ＜ 0. 05 ). The expression of CD11c in non-lymph node metastasis group ( 15.3 ± 6. 6 )was obviously higher than that in lymph node metastasis group ( 8. 6 ± 5. 1 ), ( t = 5. 44, P ＜ 0. 01 ). The expression of CD11c in non-recurrence group ( 12.3 ±7.4) was higher than that in recurrence group (9. 0± 5.3), ( t= 2.90, P ＜ 0. 01 ). The expression of CD11 c in differentiation group ( 9. 3 ± 5.3 ) was lower than that in low differentiation group ( 12. 6 ± 7. 8 ), ( t = 2. 68, P ＜ 0. 01 ). There was significant diference among groups of clinical stage (P ＜0. 01 ). The multivariate Cox analysis revealed that the risk of death in high expression group was significantly lower than that in low expression group (RR =0. 51, 95% CI=0. 22-1.16). Conclusion Detection of the CD11c expression in gastric carcinoma is beneficial to the judgment of the prognosis of gastric carcinoma and the choice of individualized treatment.
