中华眼底病杂志
中華眼底病雜誌
중화안저병잡지
CHINESE JOURNAL OF OCULAR FUNDUS DISEASES
2012年
5期
462-465
,共4页
张利娟%陶远%王玉%刘健%范传峰
張利娟%陶遠%王玉%劉健%範傳峰
장리연%도원%왕옥%류건%범전봉
脉络膜疾病/治疗%体层摄影术,光学相干%光化学疗法
脈絡膜疾病/治療%體層攝影術,光學相榦%光化學療法
맥락막질병/치료%체층섭영술,광학상간%광화학요법
Choroid diseases/therapy%Tomography,optical coherence%Photochemotherapy
目的 观察息肉样脉络膜血管病变(PCV)患眼光动力疗法(PDT)治疗前后的光相干断层扫描(OCT)图像特征,探讨其与视力的关系.方法 经荧光素眼底血管造影、吲哚青绿血管造影检查确诊为PCV的34例患者40只眼纳入研究.所有患者确诊后接受PDT治疗.治疗前后均行最小分辨角对数(logMAR)矫正视力及频域OCT检查.测量视网膜色素上皮脱离(PED)高度和基底宽度、视网膜脱离(RD)高度和基底宽度、黄斑中心区厚度(CST)及6 mm直径范围内黄斑容积(MV).治疗前患眼平均logMAR矫正视力0.66±0.32;OCT检查均可见明显PED及神经上皮脱离.对比观察分析治疗前及治疗后1、3、6、12个月OCT检测指标的变化情况及其与视力变化的相关性.结果 治疗后1、3、6、12个月,患眼平均logMAR矫正视力分别为0.58±0.27、0.48±0.38、0.51±0.37、0.50±0.36.治疗前后视力比较,治疗后1、6个月与治疗前差异均无统计学意义(t=1.22、1.96,P＞0.05);治疗后3、12个月与治疗前差异均有统计学意义(t=2.32、2.10,P＜0.05).治疗后1、3个月PED高度(t=1.07、1.50)和基底宽度(t＝1.39、1.57)与治疗前比较,差异均无统计学意义(P＞0.05);治疗后6、12个月PED高度(t=2.34、2.03)和基底宽度(t=2.08、2.00)与治疗前比较,差异均有统计学意义(P＜0.05).治疗前与治疗后1、3、6、12个月RD高度(t＝2.22、2.99、3.30、3.95)和基底宽度(t=2.55、3.33、3.11,3.92)比较,差异均有统计学意义(P＜0.05).治疗前与治疗后1,3,6,12个月CST (t=2.71、3.55、3.81、3.21)和MV(t=2.10、3.30、3.62、4.18)比较,差异均有统计学意义(P＜0.05).相关性分析结果显示,PCV患眼视力与PED基底宽度、RD高度和基底宽度、CST及MV均呈负相关(r=-0.88、-0.89、-0.92、-0.86、-0.94,P＜0.05);与PED高度无相关性(r=-0.70,P＞0.05).结论 PDT治疗后PCV患眼PED高度和基底宽度、RD高度和基底宽度、CST和MV均较治疗前降低.PCV患眼视力与PED基底宽度、RD高度和基底宽度、CST、MV呈负相关.
目的 觀察息肉樣脈絡膜血管病變(PCV)患眼光動力療法(PDT)治療前後的光相榦斷層掃描(OCT)圖像特徵,探討其與視力的關繫.方法 經熒光素眼底血管造影、吲哚青綠血管造影檢查確診為PCV的34例患者40隻眼納入研究.所有患者確診後接受PDT治療.治療前後均行最小分辨角對數(logMAR)矯正視力及頻域OCT檢查.測量視網膜色素上皮脫離(PED)高度和基底寬度、視網膜脫離(RD)高度和基底寬度、黃斑中心區厚度(CST)及6 mm直徑範圍內黃斑容積(MV).治療前患眼平均logMAR矯正視力0.66±0.32;OCT檢查均可見明顯PED及神經上皮脫離.對比觀察分析治療前及治療後1、3、6、12箇月OCT檢測指標的變化情況及其與視力變化的相關性.結果 治療後1、3、6、12箇月,患眼平均logMAR矯正視力分彆為0.58±0.27、0.48±0.38、0.51±0.37、0.50±0.36.治療前後視力比較,治療後1、6箇月與治療前差異均無統計學意義(t=1.22、1.96,P＞0.05);治療後3、12箇月與治療前差異均有統計學意義(t=2.32、2.10,P＜0.05).治療後1、3箇月PED高度(t=1.07、1.50)和基底寬度(t＝1.39、1.57)與治療前比較,差異均無統計學意義(P＞0.05);治療後6、12箇月PED高度(t=2.34、2.03)和基底寬度(t=2.08、2.00)與治療前比較,差異均有統計學意義(P＜0.05).治療前與治療後1、3、6、12箇月RD高度(t＝2.22、2.99、3.30、3.95)和基底寬度(t=2.55、3.33、3.11,3.92)比較,差異均有統計學意義(P＜0.05).治療前與治療後1,3,6,12箇月CST (t=2.71、3.55、3.81、3.21)和MV(t=2.10、3.30、3.62、4.18)比較,差異均有統計學意義(P＜0.05).相關性分析結果顯示,PCV患眼視力與PED基底寬度、RD高度和基底寬度、CST及MV均呈負相關(r=-0.88、-0.89、-0.92、-0.86、-0.94,P＜0.05);與PED高度無相關性(r=-0.70,P＞0.05).結論 PDT治療後PCV患眼PED高度和基底寬度、RD高度和基底寬度、CST和MV均較治療前降低.PCV患眼視力與PED基底寬度、RD高度和基底寬度、CST、MV呈負相關.
목적 관찰식육양맥락막혈관병변(PCV)환안광동력요법(PDT)치료전후적광상간단층소묘(OCT)도상특정,탐토기여시력적관계.방법 경형광소안저혈관조영、신타청록혈관조영검사학진위PCV적34례환자40지안납입연구.소유환자학진후접수PDT치료.치료전후균행최소분변각대수(logMAR)교정시력급빈역OCT검사.측량시망막색소상피탈리(PED)고도화기저관도、시망막탈리(RD)고도화기저관도、황반중심구후도(CST)급6 mm직경범위내황반용적(MV).치료전환안평균logMAR교정시력0.66±0.32;OCT검사균가견명현PED급신경상피탈리.대비관찰분석치료전급치료후1、3、6、12개월OCT검측지표적변화정황급기여시력변화적상관성.결과 치료후1、3、6、12개월,환안평균logMAR교정시력분별위0.58±0.27、0.48±0.38、0.51±0.37、0.50±0.36.치료전후시력비교,치료후1、6개월여치료전차이균무통계학의의(t=1.22、1.96,P＞0.05);치료후3、12개월여치료전차이균유통계학의의(t=2.32、2.10,P＜0.05).치료후1、3개월PED고도(t=1.07、1.50)화기저관도(t＝1.39、1.57)여치료전비교,차이균무통계학의의(P＞0.05);치료후6、12개월PED고도(t=2.34、2.03)화기저관도(t=2.08、2.00)여치료전비교,차이균유통계학의의(P＜0.05).치료전여치료후1、3、6、12개월RD고도(t＝2.22、2.99、3.30、3.95)화기저관도(t=2.55、3.33、3.11,3.92)비교,차이균유통계학의의(P＜0.05).치료전여치료후1,3,6,12개월CST (t=2.71、3.55、3.81、3.21)화MV(t=2.10、3.30、3.62、4.18)비교,차이균유통계학의의(P＜0.05).상관성분석결과현시,PCV환안시력여PED기저관도、RD고도화기저관도、CST급MV균정부상관(r=-0.88、-0.89、-0.92、-0.86、-0.94,P＜0.05);여PED고도무상관성(r=-0.70,P＞0.05).결론 PDT치료후PCV환안PED고도화기저관도、RD고도화기저관도、CST화MV균교치료전강저.PCV환안시력여PED기저관도、RD고도화기저관도、CST、MV정부상관.
Objective To observe the characteristics of optical coherence tomography (OCT)in polypoidal choroidal vasculopathy (PCV) before and after photodynamic therapy (PDT),and investigate its relationship with visual acuity.Methods Thirty-four PCV patients (40 eyes) diagnosed by fundus fluoresce angiography and indocyanine green angiography who had underwent the treatment of PDT,were enrolled in this study.The logMAR corrected visual acuity (CVA) were detected and the height and the base diameter of retinal pigment epithelium detachment (PED)and retinal detachment (RD),central subfield thickness (CST),macular volume (MV) were measured by OCT before and after treatment.Before the treatment,the mean logMAR CVA was 0.66 0.32 and visible PED and RD were seen on OCT images.The OCT characteristics and relationship with visual acuity were comparatively analyzed.Results One,three,six and 12 months after treatment,the mean logMAR CVA were 0.58 0.27,0.48 0.38,0.51 0.37 and 0.50 0.36.The differences of CVA were statistically significant between before-treatment and three,12 months after treatment(t=2.32,2.10; P＜0.05),but not between before-treatment and one,six months after treatment (t=1.22,1.961 P＞0.05).The differences of the height and the base diameter of PED were statistically significant between before-treatment and six,12 months after treatment (t＝2.34,2.03; P＜0.05),but not between before-treatment and one,three months after treatment (t =1.07,1.50; P ＞ 0.05).The differences of the height (t=2.22,2.99,3.30,3.95) and the base diameter (t=2.55,3.33,3.11,3.92)of RD were statistically significant between before-treatment and one,three,six and 12 months after treatment (P＜0.05).The differences of CST (t=2.71,3.55,3.81,3.21) and MV (t=2.10,3.30,3.62,4.18) were statistically significant between before-treatment and one,three,six and 12 months after treatment (P＜0.05).CVA had negative correlation with the base diameter of PED,the height and the base diameter of RD,CST and MV (r=-0.88,-0.89,-0.92,-0.86,-0.94; P＜0.05),no correlation with the height of PED (r=-0.70,P＞0.05).Conclusions The height and the base diameter of PED and RD,CST,MV of PCV are decrease after PDT.There is a negative correlation between CVA and the base diameter of PED,the height and the base diameter of RD,CST and MV.
