CAJ | 학술논문

目的以藏药佐太主要成分汞为研究对象,初步探讨其在大鼠体内的吸收和排泄情况. 方法采用微波消解技术和原子荧光光度计测定血清、肝脏组织、肾脏组织、尿液和粪便中的汞含量.结果实验1组和实验2组大鼠分别连续给予佐太7 d和21 d后,血清中汞含量较低,肾脏组织中汞含量显著增多;实验1组大鼠肝脏组织中汞含量显著增多,但实验2组显著减少;实验组大鼠尿液中检测到的汞较少,粪便中检测到大量的汞.结论佐太中的汞在大鼠体内吸收较少,主要通过粪便排出体外,长期使用在肾脏有蓄积现象.
목적 이장약좌태주요성분홍위연구대상,초보탐토기재대서체내적흡수화배설정황. 방법채용미파소해기술화원자형광광도계측정혈청、간장조직、신장조직、뇨액화분편중적홍함량.결과 실험1조화실험2조대서분별련속급여좌태7 d화21 d후,혈청중홍함량교저,신장조직중홍함량현저증다;실험1조대서간장조직중홍함량현저증다,단실험2조현저감소;실험조대서뇨액중검측도적홍교소,분편중검측도대량적홍.결론 좌태중적홍재대서체내흡수교소,주요통과분편배출체외,장기사용재신장유축적현상.
Objective To study the absorption and excretion of mercury in Tibetan medicine Zuotai in rats.Methods The mercury content in serum,hepatic tissue,kidney tissue,urine and feces were determined by microwave digestion technique and atomic fluorescence spectrometer. Results After the first and second groups of experimental rats were respectively administered Zuotai for 7 days and 21 days, the mercury contents in serum were lowered, and the mercury contents in kidney tissue were significantly increased. The mercury content of hepatic tissue was significantly increased in the first experimental group, but significantly decreased in the second experimental group. There was a little mercury in the urine of experimental rats, but a great deal of mercury was determined in the feces.Conclusion The result demonstrated that only a little mercury in Zuotai was absorbed in rats, and most of them was excreted to the environment with feces. The accumulation for mercury was detected in rats after long time and repetitive Zuotai administration.