CAJ | 학술논문

背景:踝臂指数的测量是诊断外周动脉疾病(踝臂指数<0.90)的简便有效无创的方法.患有外周动脉疾病的患者通常有局部血管的动脉粥样硬化症状,并且增加了心血管事件发生和死亡的风险.目的:总结近年来踝臂指数的流行病学研究进展,为进一步开展外周血管疾病的预防和控制提供循证医学的依据.方法:检索Pubmed数据库,纳入论点论据可靠并与踝臂指数方面的研究相关的文章,排除重复性研究或者与文章研究目的无关的文章.保留26篇文章做进一步分析.结果与结论:有研究表明外周动脉疾病能够预测心血管疾病发生率和死亡率.研究发现慢性.肾病、胰岛素使用、蛋白尿、亚甲基四氢叶酸还原酶677T基因型、高龄、女性、超重肥胖、高血压、糖尿病史、吸烟史、升高的高敏感性C反应蛋白以及较低的高密度脂蛋白等是外周动脉疾病患者的危险因素,建议应该加强对糖尿患者、高血压患者以及高脂血症等"三高"人群的非传统危险因素的检测和干预.外周动脉疾病作为动脉粥样硬化的经典指标,不仅仅能够反映下肢动脉缺血性疾病,而且也能预测到心血管疾病的发生发展.利用踝臂指数能够很好的诊断外周动脉疾病(踝臂指数<0.9).尽管外周动脉疾病能够很好的预测心血管事件的发生和死亡,但经常未被诊断和处理.目前,踝臂指数的临床筛查在国内尚未得到全面普及和推广.针对外周动脉疾病高危人群及有下肢动脉疾病风险的患者应建议进行常规踝臂指数检查.
배경:과비지수적측량시진단외주동맥질병(과비지수<0.90)적간편유효무창적방법.환유외주동맥질병적환자통상유국부혈관적동맥죽양경화증상,병차증가료심혈관사건발생화사망적풍험.목적:총결근년래과비지수적류행병학연구진전,위진일보개전외주혈관질병적예방화공제제공순증의학적의거.방법:검색Pubmed수거고,납입론점론거가고병여과비지수방면적연구상관적문장,배제중복성연구혹자여문장연구목적무관적문장.보류26편문장주진일보분석.결과여결론:유연구표명외주동맥질병능구예측심혈관질병발생솔화사망솔.연구발현만성.신병、이도소사용、단백뇨、아갑기사경협산환원매677T기인형、고령、녀성、초중비반、고혈압、당뇨병사、흡연사、승고적고민감성C반응단백이급교저적고밀도지단백등시외주동맥질병환자적위험인소,건의응해가강대당뇨환자、고혈압환자이급고지혈증등"삼고"인군적비전통위험인소적검측화간예.외주동맥질병작위동맥죽양경화적경전지표,불부부능구반영하지동맥결혈성질병,이차야능예측도심혈관질병적발생발전.이용과비지수능구흔호적진단외주동맥질병(과비지수<0.9).진관외주동맥질병능구흔호적예측심혈관사건적발생화사망,단경상미피진단화처리.목전,과비지수적림상사사재국내상미득도전면보급화추엄.침대외주동맥질병고위인군급유하지동맥질병풍험적환자응건의진행상규과비지수검사.
BACKGROUDN:Ankle-brachial index was a simple and effective non-invasive method to diagnose peripheral arterial disease (ankle-brachial index < 0.90). Patients suffering from peripheral arterial disease usually indicated partial vascular symptoms of atherosclerosis and increased cardiovascular events and mortality risks. OBJECTIVE: To summarize the epidemiological progress of ankle-brachial index so as to further provide evidences for prevention and control of peripheral arterial disease.METHODS: Experimental data were retrieved from Pubmed database. Articles about ankle-brachial index were included, but articles about duplicated research and unrelated articles were excluded. A total of 26 articles were finally included.RESULTS AND CONCLUSION: Studies have shown that peripheral arterial disease could predict the incidence and mortality of cardiovascular disease. Studies found that the risk factors of peripheral arterial disease included chronic kidney disease, insulin use, proteinuria, MTHFR 677T genotype, age, female, overweight and obesity, hypertension, diabetes history, smoking history,elevated high-sensitivity C-reactive protein and low high-density lipoprotein. It was recommended that the risk factors should be strongly detected in patients with diabetes, hypertension, and hyperlipidemia. Peripheral arterial disease, as a atherosclerosis classic indicator, not only reflects the lower extremity arterial ischemic disease, but also predicts the occurrence and development of cardiovascular disease. The use of ankle-brachial index is a good diagnostic indicator of peripheral arterial disease (ankle-brachial index < 0.9). Although the peripheral arterial disease is a good prediction of cardiovascular events and death, it is not often diagnosed and treated. At present, clinical screening of ankle-brachial index in our country has not been universally popularized and promoted. High-risk population for peripheral arterial disease and lower extremity arterial disease should be recommended for routine checks of ankle-brachial index.