中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2011年
2期
105-108
,共4页
糖尿病,2型%微血管病变%色素上皮衍生因子%单核苷酸多态性
糖尿病,2型%微血管病變%色素上皮衍生因子%單覈苷痠多態性
당뇨병,2형%미혈관병변%색소상피연생인자%단핵감산다태성
Diabetes，type 2%Microangiopathy%Pigment epithelium-derived factor%Single nucleotide polymorphism
目的 观察色素上皮衍生因子(PEDF)启动子区单核苷酸多态性(SNP)与糖尿病微血管病变的关系.方法 将271例T2DM患者分为无糖尿病微血管病变组105例,合并糖尿病微血管并发症组166例,分析PEDF基因启动子区rs12150053 T/C及rs12948385 G/A的基因型和等位基因频率.结果两个SNPs位点等位基因频率均有统计学差异(P<0.05),rs12948385位点基因型频率也有统计学差异(P<0.05).结论 PEDF启动子区多态性位点可能是我国北方汉族人群糖尿病微血管病变发病的危险因素之一.
目的 觀察色素上皮衍生因子(PEDF)啟動子區單覈苷痠多態性(SNP)與糖尿病微血管病變的關繫.方法 將271例T2DM患者分為無糖尿病微血管病變組105例,閤併糖尿病微血管併髮癥組166例,分析PEDF基因啟動子區rs12150053 T/C及rs12948385 G/A的基因型和等位基因頻率.結果兩箇SNPs位點等位基因頻率均有統計學差異(P<0.05),rs12948385位點基因型頻率也有統計學差異(P<0.05).結論 PEDF啟動子區多態性位點可能是我國北方漢族人群糖尿病微血管病變髮病的危險因素之一.
목적 관찰색소상피연생인자(PEDF)계동자구단핵감산다태성(SNP)여당뇨병미혈관병변적관계.방법 장271례T2DM환자분위무당뇨병미혈관병변조105례,합병당뇨병미혈관병발증조166례,분석PEDF기인계동자구rs12150053 T/C급rs12948385 G/A적기인형화등위기인빈솔.결과량개SNPs위점등위기인빈솔균유통계학차이(P<0.05),rs12948385위점기인형빈솔야유통계학차이(P<0.05).결론 PEDF계동자구다태성위점가능시아국북방한족인군당뇨병미혈관병변발병적위험인소지일.
Objective To investigate the association of promoter polymorphism of pigment epithelium- derived factor(PEDF) with diabetic microangiopathy.Methods271 inpatients with type 2 diabetes mellitus were divided into control group (T2DM without diabetic microangiopathy, n=105) and microangiopathy group (n=166). Genotypes of the rs12150053 T/C and rs12948385 G/A were analyzed.ResultsThe distribution of T/T, C/T and C/C genotypes of rs12150053 had no significant difference between the two groups (P=0.099). The frequencies of C and T allele showed significant difference (P=0.047). The distribution of G/G, G/A, and A/A genotypes and the frequencies of G and A allele of rs12948385 showed significant difference between the two groups (P=0.024, P=0.025). Conclusions The SNP of rs12150053 T/C and rs12948385 G/A in the promoter region of PEDF might be the independent risk factor for diabetic microangiopathy.
