CAJ | 학술논문

目的:观察胰岛素强化治疗对2型糖尿病(T2DM)患者静息能量消耗(REE)的影响.方法:对26例T2DM患者经胰岛素强化治疗前后的临床生化指标、炎症因子及REE进行比较分析.结果胰岛素强化治疗能显著降低REE,用体重(Wt)校正后REE/Wt下降约10.4 %(P=0.006).多元回归分析提示REE与FPG、高敏C反应蛋白(hsC-RP)、白介素6(IL-6)正相关(P<0.05).结论:胰岛素强化治疗可降低T2DM患者的REE,REE的降低与血糖下降及炎症反应的改善相关.
목적:관찰이도소강화치료대2형당뇨병(T2DM)환자정식능량소모(REE)적영향.방법:대26례T2DM환자경이도소강화치료전후적림상생화지표、염증인자급REE진행비교분석.결과이도소강화치료능현저강저REE,용체중(Wt)교정후REE/Wt하강약10.4 %(P=0.006).다원회귀분석제시REE여FPG、고민C반응단백(hsC-RP)、백개소6(IL-6)정상관(P<0.05).결론:이도소강화치료가강저T2DM환자적REE,REE적강저여혈당하강급염증반응적개선상관.
Objective To observe the effect of intensive insulin therapy (IIT) on resting energy expenditure(REE) in patients with type 2 diabetes mellitus(T2DM). Methods Pre- and post-treatment data and inflammation biomarkers of 26 T2DM patients were recorded before and after IIT. Results After IIT the REE/Wt was reduced by about 10.4% (P=0.006) after adjusting body weight.REE/Wt was positively correlated with FPG, hs-CRP , IL-6 (all P＜0.05). Conclusion Intensive insulin therapy in T2DM may lead to decline of REE, which may be related to the decrease in blood glucose and insulin-related anti-inflammatory effects.