CAJ | 학술논문

正常的黏液纤毛清除功能要求黏液具有最佳的黏弹性和厚度,而足够数量、结构完整和一定摆动频率的纤毛则更重要.由于慢性阻塞性肺疾病,原发性纤毛运动障碍、囊性纤维化等多种疾病均存在纤毛结构和功能异常或纤毛周围的黏液流变学特征改变,因此气道黏液纤毛清除功能成为探索相关治疗的新领域之一.本文就影响纤毛结构及运动的因素及相关的呼吸系统疾病的研究进展作综述.
정상적점액섬모청제공능요구점액구유최가적점탄성화후도,이족구수량、결구완정화일정파동빈솔적섬모칙경중요.유우만성조새성폐질병,원발성섬모운동장애、낭성섬유화등다충질병균존재섬모결구화공능이상혹섬모주위적점액류변학특정개변,인차기도점액섬모청제공능성위탐색상관치료적신영역지일.본문취영향섬모결구급운동적인소급상관적호흡계통질병적연구진전작종술.
The normal mucociliary clearance system (MCC) requires not only mucus with optimum of viscoelastic and thickness, but also enough cilia with structural integrity and sufficient cilia beat frequency(CBF). Abnormality of ciliary structure and function, CBF or surface properties of mucus was found in several respiratory diseases, such as chronic obstructive pulmonary diseases, primary ciliary dyskinesia,cystic fibrosis,etc. Which implies the MCC should be new area for research on treatment of respiratory diseases. The review will focus on the research progress of airway ciliary function and related respiratory diseases.