CAJ | 학술논문

目的观察氯沙坦钾和依那普利联合治疗Ⅳ期糖尿病肾病(DN)的疗效.方法将74例Ⅳ期DN患者随机分为三组,氯沙坦钾组:口服氯沙坦钾100 mg,1次/d;依那普利组;口服依那普利10 mg,1次/d;联合治疗组:同时服用以上两种药物,且剂量不变.三组患者治疗均在3年以上.监测治疗前后24 h尿蛋白定量及血清肌酐.结果三组患者24 h尿蛋白定量较治疗前均下降,差异有统计学意义(P＜0.05),联合治疗组效果更好(P＜0.01).血清肌酐仅联合治疗组下降,差异有统计学意义(P＜0.05).结论联合应用氯沙坦钾和依那普利可以有效控制Ⅳ期DN患者蛋白尿,延缓肾脏病进展.
목적 관찰록사탄갑화의나보리연합치료Ⅳ기당뇨병신병(DN)적료효.방법 장74례Ⅳ기DN환자수궤분위삼조,록사탄갑조:구복록사탄갑100 mg,1차/d;의나보리조;구복의나보리10 mg,1차/d;연합치료조:동시복용이상량충약물,차제량불변.삼조환자치료균재3년이상.감측치료전후24 h뇨단백정량급혈청기항.결과 삼조환자24 h뇨단백정량교치료전균하강,차이유통계학의의(P＜0.05),연합치료조효과경호(P＜0.01).혈청기항부연합치료조하강,차이유통계학의의(P＜0.05).결론 연합응용록사탄갑화의나보리가이유효공제Ⅳ기DN환자단백뇨,연완신장병진전.
Objective To observe the curative effect that losartan potassium combined with enalapril used in treating Ⅳ phase diabetic nephropathy(DN). Methods Divided 74 Ⅳ phase DN suffers into 3 groups randomly.Losartan group:taken losartan potassium lablets 100 mg once every day orally,enalapril group:taken enalapril tablets 10 mg once every day orally,consociation group:taken the two drugs above ai one time with the same dosage.The treatment in the 3 groups were all above 3 years.monitoring the 24-hour albuminuria and SCr back and forth the treatment.Results It worthed statistics meaning that the 24-hour albuminuria in the 3 groups all declined(P＜0.05).The effect of consociation group did better(P＜O.01).In term of SCr,it declined in the consociation group worthed statisties meaning only.Conclusion The consociation application with losartan potassium and enalapril can control the proteinuria of Ⅳ phage DN suffers efficiently as well as defer process of kidney diseases.