CAJ | 학술논문

抽取沈阳地区孕早期妇女505例,通过问卷方式获得其对富含大豆制品食物的摄入频度及相关背景资料,分组如下:(1)经常摄入组:≥3次/周；(2)一般摄入组:2次/月～3次/周；(3)偶尔摄入组:≤2次/月.采用固相化学发光酶免疫分析法测定血清TSH、FT4,并对其中95名孕妇的尿异黄酮浓度进行了检测.在调查对象中,经常摄入富含大豆制品食物者占18.6％,一般摄入组占62.6％,偶尔摄入者占18.8％.3组在年龄、甲状腺疾病史、家族史、血清FT4和TSH水平及甲状腺功能紊乱患病率方面差异均无统计学意义.经常摄入组尿中尿大豆苷元、尿染料木黄酮水平高于其他2组,血清FT4、TSH水平与尿异黄酮浓度无显著相关.本研究提示在碘充足地区,孕早期妇女进食富含大豆的食物未影响甲状腺功能.
추취침양지구잉조기부녀505례,통과문권방식획득기대부함대두제품식물적섭입빈도급상관배경자료,분조여하:(1)경상섭입조:≥3차/주；(2)일반섭입조:2차/월～3차/주；(3)우이섭입조:≤2차/월.채용고상화학발광매면역분석법측정혈청TSH、FT4,병대기중95명잉부적뇨이황동농도진행료검측.재조사대상중,경상섭입부함대두제품식물자점18.6％,일반섭입조점62.6％,우이섭입자점18.8％.3조재년령、갑상선질병사、가족사、혈청FT4화TSH수평급갑상선공능문란환병솔방면차이균무통계학의의.경상섭입조뇨중뇨대두감원、뇨염료목황동수평고우기타2조,혈청FT4、TSH수평여뇨이황동농도무현저상관.본연구제시재전충족지구,잉조기부녀진식부함대두적식물미영향갑상선공능.
Data were collected through questionnaire from 505 women enrolled during early pregnancy.Based on soy intake frequency,the subjects were divided into three groups:frequent (three or more times per week),conventional ( more than twice per month but less than three times per week),and occasional ( two or fewer times per month).Serum TSH and FT4 were measured by chemiluminescence immunoassay.The urinary concentrations of two primary isoflavones (daidzein and genistein) and creatinine were further assessed in 95 subjects from the three groups.The percentages of frequent,conventional,and occasional consumers were 18.6％,62.6％,and 18.8％,respectively.No difference was found in age,medical records,family history of thyroid diseases,serum FT4,TSH,and prevalence of thyroid dysfunctions among three groups. Both urinary daidzein and genistein levels were significantly higher in the frequent consumers compared with the other two groups.No correlations were found between urinary isoflavone levels and serum FT4 or TSH.These findings suggest that dietary soy consumption during early pregnancy seems not to be associated with the development of thyroid dysfunction.