中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2012年
7期
676-680
,共5页
李晓宾%鹿寒冰%董瑞国%李传玲%朱士光%郭靖%安晓雷
李曉賓%鹿寒冰%董瑞國%李傳玲%硃士光%郭靖%安曉雷
리효빈%록한빙%동서국%리전령%주사광%곽정%안효뢰
脑梗死%脑水肿%亚低温%磁共振成像%模型,动物
腦梗死%腦水腫%亞低溫%磁共振成像%模型,動物
뇌경사%뇌수종%아저온%자공진성상%모형,동물
Cerebral infarction%Cerebral edema%Mild hypothermia%Magnetic resonance imaging%Model,animal
目的 探讨亚低温对大鼠脑梗死后脑水肿的干预作用.方法 12只雄性SD大鼠按随机数字表法分为对照组(r=6)及亚低温组(n=6).2组均采用线栓法阻塞大脑中动脉以制作局灶性脑梗死模型,亚低温组在造模后亚低温干预3h.在造模后6h、1d、3d、5d、7d时对2组大鼠行MRI扫描,测量计算梗死体积、水肿吸收率,梗死区T1WI、T2WI、FLAIR、DWI序列的信号强度比(SIR)及信号强度比相对变化率(△SIR).结果 亚低温组大鼠在造模后3d、5d、7d时梗死体积均明显小于对照组,差异有统计学意义(P＜0.05).亚低温组大鼠造模后7d相对于3d时水肿吸收率明显高于对照组,差异有统计学意义(P＜0.05).亚低温组大鼠在造模后3d、5d、7d时T1Wl序列SIR均明显高于对照组,T2WI及FLAIR序列SIR均明显低于对照组,差异有统计学意义(P＜0.05)；亚低温组大鼠在造模后7d时DWI序列SIR明显低于对照组,差异有统计学意义(P＜0.05).亚低温组大鼠T2WI 、FLAIR及DWI序列△SIR均明显高于对照组,差异有统计学意义(P＜0.05).结论 亚低温对大鼠脑梗死后脑水肿有明显的抑制作用.
目的 探討亞低溫對大鼠腦梗死後腦水腫的榦預作用.方法 12隻雄性SD大鼠按隨機數字錶法分為對照組(r=6)及亞低溫組(n=6).2組均採用線栓法阻塞大腦中動脈以製作跼竈性腦梗死模型,亞低溫組在造模後亞低溫榦預3h.在造模後6h、1d、3d、5d、7d時對2組大鼠行MRI掃描,測量計算梗死體積、水腫吸收率,梗死區T1WI、T2WI、FLAIR、DWI序列的信號彊度比(SIR)及信號彊度比相對變化率(△SIR).結果 亞低溫組大鼠在造模後3d、5d、7d時梗死體積均明顯小于對照組,差異有統計學意義(P＜0.05).亞低溫組大鼠造模後7d相對于3d時水腫吸收率明顯高于對照組,差異有統計學意義(P＜0.05).亞低溫組大鼠在造模後3d、5d、7d時T1Wl序列SIR均明顯高于對照組,T2WI及FLAIR序列SIR均明顯低于對照組,差異有統計學意義(P＜0.05)；亞低溫組大鼠在造模後7d時DWI序列SIR明顯低于對照組,差異有統計學意義(P＜0.05).亞低溫組大鼠T2WI 、FLAIR及DWI序列△SIR均明顯高于對照組,差異有統計學意義(P＜0.05).結論 亞低溫對大鼠腦梗死後腦水腫有明顯的抑製作用.
목적 탐토아저온대대서뇌경사후뇌수종적간예작용.방법 12지웅성SD대서안수궤수자표법분위대조조(r=6)급아저온조(n=6).2조균채용선전법조새대뇌중동맥이제작국조성뇌경사모형,아저온조재조모후아저온간예3h.재조모후6h、1d、3d、5d、7d시대2조대서행MRI소묘,측량계산경사체적、수종흡수솔,경사구T1WI、T2WI、FLAIR、DWI서렬적신호강도비(SIR)급신호강도비상대변화솔(△SIR).결과 아저온조대서재조모후3d、5d、7d시경사체적균명현소우대조조,차이유통계학의의(P＜0.05).아저온조대서조모후7d상대우3d시수종흡수솔명현고우대조조,차이유통계학의의(P＜0.05).아저온조대서재조모후3d、5d、7d시T1Wl서렬SIR균명현고우대조조,T2WI급FLAIR서렬SIR균명현저우대조조,차이유통계학의의(P＜0.05)；아저온조대서재조모후7d시DWI서렬SIR명현저우대조조,차이유통계학의의(P＜0.05).아저온조대서T2WI 、FLAIR급DWI서렬△SIR균명현고우대조조,차이유통계학의의(P＜0.05).결론 아저온대대서뇌경사후뇌수종유명현적억제작용.
[Objective]To study the intervention effect of mild hypotherrnia on cerebral edema in rats after cerebral infarction.[Methods]Twelve male SD rats were randomized into control group (n--6) and mild hypotherma treatment group (n=6).The rat models of focal cerebral infarction were established with obstructing the middle cerebral artery of rats by suture emboli.Rats of the mild hypotherma treatment group were treated by mild hypotherm for 3 h after the models were established.MRI was performed at 6 h,and 1,3,5 and 7 d after the success of model making.Cerebral infarction volume,absorption rate of edema,and signal intensity ratios (SIRs) ofTIWl,T2WI,FLAIR and DWI sequencas in the infarction zones,and relative variance ratio of SIR (△SIR) were measured and calculated.[Results] In the mild hypotherma treatment group,the cerebral infarction volumes 3,5 and 7 d after the models were established were significantly decreased as compared with those in the control group (P＜0.05);the absorption rate of edema (the 7th d against the 3th d of infarction) in the the mild hypotherma treatment group was significantly higher than that in the control group (P＜0.05).Three,5 and 7 d after infarction,the SIRs of TIWI were all obviously higher than those in the control group,and the SIRs of T2WI and FLAIR were all significantly lower than those in the control group (P＜0.05).The SIR of DWI in the mild hypotherma treatment group was obviously lower than that in the control group 7 d after infarction (P＜0.05).The △SIRs of T2Wl,FLAIR and DWI in the mild hypotherma treatment group were significantly higher than those in the control group (P＜0.05).[Conclusion] Mild hypothermia has a significant inhibition effect on cerebral edema in rats after cerebral infarction.
