CAJ | 학술논문

目的定量考察浸润性与膨胀性肿瘤的生长形态特征并给出一种简洁的分析方法.方法选取33例6类肿瘤患者的CT/MRI图像进行了定量评估和数值计算分析.定量评估参数包括肿瘤边界的分形维数、肿瘤内部的异质性及形成包块化程度.结果 (1)浸润性生长肿瘤较膨胀性生长肿瘤具有更大的边界分形维,显示浸润性生长肿瘤边界的复杂性与开放性更加突出.(2)上述两类肿瘤内部都存在异质性,并由此异质性形成肿物包块;异质性与包块化程度基本满足正线性相关,其中膨胀性生长肿瘤比浸润性生长肿瘤具有更大的包块化生长系数.结论本研究所给出的分形维数、肿瘤内部的异质性及形成包块化程度分析方法对于定量评价肿瘤的进展有一定启示性和实用价值,有助于医学影像图像的定量分析及计算机辅助诊断新方法的建立.
목적 정량고찰침윤성여팽창성종류적생장형태특정병급출일충간길적분석방법.방법 선취33례6류종류환자적CT/MRI도상진행료정량평고화수치계산분석.정량평고삼수포괄종류변계적분형유수、종류내부적이질성급형성포괴화정도.결과 (1)침윤성생장종류교팽창성생장종류구유경대적변계분형유,현시침윤성생장종류변계적복잡성여개방성경가돌출.(2)상술량류종류내부도존재이질성,병유차이질성형성종물포괴;이질성여포괴화정도기본만족정선성상관,기중팽창성생장종류비침윤성생장종류구유경대적포괴화생장계수.결론 본연구소급출적분형유수、종류내부적이질성급형성포괴화정도분석방법대우정량평개종류적진전유일정계시성화실용개치,유조우의학영상도상적정량분석급계산궤보조진단신방법적건립.
Objective To investigate quantitatively the proliferation of tumors in characteristic of either expansive or infihrative growth pattern.Methods The CT/MRI images of 34 tumor patients with 6 different pathological types were adopted to undergo quantitative evaluation of the growth pattern of these tumors.Three key parameters,fractal dimension(Df)of the border between the tumor and neighboring tissues,degree of heterogeneity(H),and clumpiness(C)inside the tumor,were computed numerically.Results The Df values of the infiltrative tumors were higher than those of the expansive tumors.thus revealing the more evident complexity and openness of the border of infiltrative tumor.Heterogeneity and clumpiness existed within both expansive and infihrative tumors.The clumpiness derived from heterogeneitv and they were correlated positively with each other.The growth coefficient of clumpiness of the expansive tumor was greater than that of the infiltrative tumor.Conclusion The method to anaiyze the fractal dimension of tumor border,and degrees of heterogeneity and clumpiness within a tumor presented in this paper gives some enlightenment to the fundamental research in characterizing tumor growth and shows practical value in clinical diagnosis of tumor,and may be of benefit to the quantitative eyaluation of radiological images and computer.aided diagnosis.