CAJ | 학술논문

羟基磷灰右是一种优质的医用生物材料,而纳米羟基磷灰行更具有独特的性能.羟基磷灰石纳米粒子对多种痛细胞的生长均有抑制作用,而对正常细胞无影响,在肿瘤治疗中可能具有较好的选择性.其机制可能与影响膜信号传递、影响核酸合成、阻滞细胞周期、引起细胞凋亡等有关.文章简要介绍了纳米羟基磷灰石的独特结构和性能.综合分析纳米羟基磷灰石在肿瘤领域的研究进展,探讨纳米羟基磷灰石作为新的抗肿瘤药物在临床中应用的可能性.
간기린회우시일충우질적의용생물재료,이납미간기린회행경구유독특적성능.간기린회석납미입자대다충통세포적생장균유억제작용,이대정상세포무영향,재종류치료중가능구유교호적선택성.기궤제가능여영향막신호전체、영향핵산합성、조체세포주기、인기세포조망등유관.문장간요개소료납미간기린회석적독특결구화성능.종합분석납미간기린회석재종류영역적연구진전,탐토납미간기린회석작위신적항종류약물재림상중응용적가능성.
Hydroxyapatite has already been considered as an excellent medical biomaterial.and nanometer hydroxyapatite possesses special characteristics.Hydroxyapatite nanoparticles can inhibit the growth of a wide range of cancer cells.but have no effect on normal cells.thus it has a better selectivity in the treatment of cancer.The anti-tumor mechanism of nano-hydroxyapatite is relevant on the following factors:role in the cell membrane,affecting DNA synthesis,inducing cell cycle blockage and apoptosis,impacting the activity of telomerase.This study is designed to introduce the specific structure and characterjstics of nano-hydroxyapatite,analyze the research progress of nano-hydroxyapatite in tumor field.and discuss the possibility of nano-hydroxyapatite as a new anti-cancer drug in clinical application.