时珍国医国药
時珍國醫國藥
시진국의국약
LISHIZHEN MEDICINE AND MATERIA MEDICA RESEARCH
2010年
4期
777-779
,共3页
李文宏%罗晓健%余日跃%张国松%王文哲%崔雪娜
李文宏%囉曉健%餘日躍%張國鬆%王文哲%崔雪娜
리문굉%라효건%여일약%장국송%왕문철%최설나
遥测生理信号采集系统%复方丹参片%垂体后叶素%急性心肌缺血%心功能
遙測生理信號採集繫統%複方丹參片%垂體後葉素%急性心肌缺血%心功能
요측생리신호채집계통%복방단삼편%수체후협소%급성심기결혈%심공능
Dataquest system%Fufang Danshen Tablets%Isoprotereno%Acute myocardial ischemia%Myocardial function
目的 观察复方丹参片对急性心肌缺血犬心功能的影响.方法 Beagle犬埋置D70-PCTP植入子,静脉注射垂体后叶素制备急性心肌缺血模型,采用遥测生理信号采集系统实时监测清醒动物的ECG、dp/dt_(max)、dp/dt_(min)、心率、左室内压等指标,观察复方丹参片对心肌缺血犬心功能指标的改善作用.结果 复方丹参片可明显降低心肌缺血急性期T波幅度,提高dp/dt_(max)、dp/dt_(min),并能升高收缩压、减慢心率,表明复方丹参片可改善缺血心肌的缺血状态和舒缩功能,提高缺血心肌的作功效能.结论 复方丹参片对犬急性心肌缺血有良好的保护作用.
目的 觀察複方丹參片對急性心肌缺血犬心功能的影響.方法 Beagle犬埋置D70-PCTP植入子,靜脈註射垂體後葉素製備急性心肌缺血模型,採用遙測生理信號採集繫統實時鑑測清醒動物的ECG、dp/dt_(max)、dp/dt_(min)、心率、左室內壓等指標,觀察複方丹參片對心肌缺血犬心功能指標的改善作用.結果 複方丹參片可明顯降低心肌缺血急性期T波幅度,提高dp/dt_(max)、dp/dt_(min),併能升高收縮壓、減慢心率,錶明複方丹參片可改善缺血心肌的缺血狀態和舒縮功能,提高缺血心肌的作功效能.結論 複方丹參片對犬急性心肌缺血有良好的保護作用.
목적 관찰복방단삼편대급성심기결혈견심공능적영향.방법 Beagle견매치D70-PCTP식입자,정맥주사수체후협소제비급성심기결혈모형,채용요측생리신호채집계통실시감측청성동물적ECG、dp/dt_(max)、dp/dt_(min)、심솔、좌실내압등지표,관찰복방단삼편대심기결혈견심공능지표적개선작용.결과 복방단삼편가명현강저심기결혈급성기T파폭도,제고dp/dt_(max)、dp/dt_(min),병능승고수축압、감만심솔,표명복방단삼편가개선결혈심기적결혈상태화서축공능,제고결혈심기적작공효능.결론 복방단삼편대견급성심기결혈유량호적보호작용.
Objective To observe the effects of Fufang Danshen Tablets on myocardial function in acute myocardial ischemia canine.Methods D70-PCTP implants were embeded in beagle canine,acute myocardial ischemia model was prepared by Isoprotereno intravenous injection.Indexes of myocardial functions,such as dp/dt_(max),dp/dt_(min),heart rate,left ventricular pressure ect.,were monitored in sober animals at real time by Dataquest ART 4.0 system,improvement of Fufang Danshen tablets on indexes of myocardial functions decreased by myocardial ischemia were observed.Results Decreased dp/dt_(max),dp/dt_(min) and systolic pressure ect.caused by myocardial ischemia were promoted by Fufang Danshen tablets.Conclusion Fufang Danshen Tablets has perfect protective effects on acute myocardial ischemia.
