中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
18期
22-24
,共3页
喉肿瘤%受体,表皮生长因子%环氧化酶2%逆转录聚合酶链反应
喉腫瘤%受體,錶皮生長因子%環氧化酶2%逆轉錄聚閤酶鏈反應
후종류%수체,표피생장인자%배양화매2%역전록취합매련반응
Laryngeal neoplasms%Receptor,epidermal growth factor%Cyclooxygenase 2%Reverse transcriptase polymerase chain reaction
目的 检测喉鳞癌组织中表皮生长因子受体(EGFR)和环氧合酶-2(COX-2)的表达,探讨其相关的临床意义.方法 收集54例喉鳞癌手术切除组织(喉鳞癌组)及癌旁非癌喉黏膜组织(癌旁对照组).按组织分化程度、颈淋巴结有无转移、临床TNM分期进行分组比较EGFR和COX-2的表达.结果 EGFR在喉鳞癌组的阳性表达率为63.0％( 34/54),高于癌旁对照组的42.6％(23/54) (P＜ 0.05),COX-2在喉鳞癌组的阳性表达率为68.5％(37/54),高于癌旁对照组的35.2％(19/54) (P＜ 0.01).喉鳞癌组中EGFR和COX-2的表达量分别为0.584±0.136和0.561±0.134,而癌旁对照组分别为0.161±0.045和0.114±0.027,两组比较差异有统计学意义(P＜0.01).EGFR和COX-2的表达量在不同组织分化程度、颈淋巴结有无转移、不同临床TNM分期之间比较差异有统计学意义(P＜0.05或＜0.01).相关性分析显示喉鳞癌组织中EGFR与COX-2的表达呈正相关(r=0.602,P＜0.01).结论 EGFR和COX-2在喉鳞癌的发生发展中起一定的作用,在肿瘤良恶性的鉴别诊断、临床分期以及判断预后等方面,具有显著的临床意义.
目的 檢測喉鱗癌組織中錶皮生長因子受體(EGFR)和環氧閤酶-2(COX-2)的錶達,探討其相關的臨床意義.方法 收集54例喉鱗癌手術切除組織(喉鱗癌組)及癌徬非癌喉黏膜組織(癌徬對照組).按組織分化程度、頸淋巴結有無轉移、臨床TNM分期進行分組比較EGFR和COX-2的錶達.結果 EGFR在喉鱗癌組的暘性錶達率為63.0％( 34/54),高于癌徬對照組的42.6％(23/54) (P＜ 0.05),COX-2在喉鱗癌組的暘性錶達率為68.5％(37/54),高于癌徬對照組的35.2％(19/54) (P＜ 0.01).喉鱗癌組中EGFR和COX-2的錶達量分彆為0.584±0.136和0.561±0.134,而癌徬對照組分彆為0.161±0.045和0.114±0.027,兩組比較差異有統計學意義(P＜0.01).EGFR和COX-2的錶達量在不同組織分化程度、頸淋巴結有無轉移、不同臨床TNM分期之間比較差異有統計學意義(P＜0.05或＜0.01).相關性分析顯示喉鱗癌組織中EGFR與COX-2的錶達呈正相關(r=0.602,P＜0.01).結論 EGFR和COX-2在喉鱗癌的髮生髮展中起一定的作用,在腫瘤良噁性的鑒彆診斷、臨床分期以及判斷預後等方麵,具有顯著的臨床意義.
목적 검측후린암조직중표피생장인자수체(EGFR)화배양합매-2(COX-2)적표체,탐토기상관적림상의의.방법 수집54례후린암수술절제조직(후린암조)급암방비암후점막조직(암방대조조).안조직분화정도、경림파결유무전이、림상TNM분기진행분조비교EGFR화COX-2적표체.결과 EGFR재후린암조적양성표체솔위63.0％( 34/54),고우암방대조조적42.6％(23/54) (P＜ 0.05),COX-2재후린암조적양성표체솔위68.5％(37/54),고우암방대조조적35.2％(19/54) (P＜ 0.01).후린암조중EGFR화COX-2적표체량분별위0.584±0.136화0.561±0.134,이암방대조조분별위0.161±0.045화0.114±0.027,량조비교차이유통계학의의(P＜0.01).EGFR화COX-2적표체량재불동조직분화정도、경림파결유무전이、불동림상TNM분기지간비교차이유통계학의의(P＜0.05혹＜0.01).상관성분석현시후린암조직중EGFR여COX-2적표체정정상관(r=0.602,P＜0.01).결론 EGFR화COX-2재후린암적발생발전중기일정적작용,재종류량악성적감별진단、림상분기이급판단예후등방면,구유현저적림상의의.
Objective To detect the expression of epidermal growth factor receptor (EGFR) and cyclooxygenase-2(COX-2 ) in laryngeal squamous cell carcinoma and to investigate their clinical significance.Methods Resected tissue of laryngeal squamous cell carcinoma (observation group)and adjacent normal laryngeal mucosa ( control group) from 54 patients were collectod.Accooding to histological differentiation degreo,cervical lymph node metastasis,clinical TNM staging,EGFR and COX-2 were compared.Results The expression rate of EGFR in observation group [63.0％ (34/54)] was higher than that in control group [42.6％ (23/54)] (P ＜ 0.05 ).And COX-2 in observation group [68.5％(37/54)] was higher than that in control group [35.2％ (19/54)] (P ＜0.01).The expression of EGFR and COX-2 in observation group (0.584 ±0.136,0.561 ±0.134) were significantly higher than those in control group (0.161 ±0.045,0.114 ±0.027),respectively (P ＜0.01).The expression of EGFR and COX-2 had significant difference among histological differentiation degree,with or without cervical lymph node metastasis,different clinical TNM staging (P ＜ 0.05 or ＜ 0.01 ).Correlation analysis showed that the expression of EGFR and COX-2 in laryngeal squamous cell carcinoma had positive correlation (r =0.602,P ＜ 0.01 ).Conclusions The expression of EGFR and COX-2 have some contribution to the incidence and development of laryngeal squamots cell carcinoma.They can be used for the different diagnosis of benign and malignant carcinoma,clinical staging and prognosis estimating.They have significant clinical values.
