CAJ | 학술논문

目的探讨抗N-甲基-M-天冬氨酸(NMDA)受体脑炎的临床特点、诊断及治疗.方法报道1例伴卵巢畸胎瘤的抗NMDA受体脑炎患者的临床表现及诊治过程,并总结其临床特征.结果患者为青年女性,表现为精神行为异常及抽搐,意识障碍及通气不足.早期发现畸胎瘤,脑脊液中抗NMDA受体抗体阳性.行畸胎瘤手术切除,联合静脉用免疫球蛋白和激素冲击治疗,患者临床痊愈.结论抗NMDA受体脑炎是一种自身免疫性的、能用血清学方法诊断的疾病.早期明确诊断和给予及时治疗,预后良好.
목적 탐토항N-갑기-M-천동안산(NMDA)수체뇌염적림상특점、진단급치료.방법보도1례반란소기태류적항NMDA수체뇌염환자적림상표현급진치과정,병총결기림상특정.결과환자위청년녀성,표현위정신행위이상급추휵,의식장애급통기불족.조기발현기태류,뇌척액중항NMDA수체항체양성.행기태류수술절제,연합정맥용면역구단백화격소충격치료,환자림상전유.결론 항NMDA수체뇌염시일충자신면역성적、능용혈청학방법진단적질병.조기명학진단화급여급시치료,예후량호.
Objective To investigate the clinical presentation,diagnosis,and surgical management of anti-N-methyl-D-aspartate (NMDA) receptor encephalitis.Methods One case of anti-NMDA receptor encephalitis in a previously healthy 17-year-old female related to the development of NMDA receptor autoantibodies triggered by an ovarian teratoma was reported.The related literature was reviewed and the clinical feature was summarized.Results Removal of the ovarian teratoma combined with intravenous immuneglobulin and corticosteroid proved curative with eventual resolution of the paraneoplastic disease process and associated psychiatric symptoms.Conclusion Increasingly,reports of anti-NMDA receptor encephalitis associated with ovarian teratomas,as well as a novel assay to measure these antibodies suggest an etiology for this disease process that may be amenable to prompt surgical excision.