CAJ | 학술논문

当人工血管移植体内后,材料表面会吸附γ-球蛋白或纤维蛋白原,易于使血液中细胞成分如血小板黏附于表面,血小板-旦被吸附,可以变成扁平状而被激活,从而导致血小板不可逆聚集而产生血栓.在大于6 mm口径人工血管移植中,有较高的血管通畅率,而在小口径人工血管(<6 mm)移植中,由于低血流量状态,易形成血栓.因此有必要对小门径人工血管进行表面改性,增加血液相容性,主要改性方法有改变人工血管材料表面结构,增加人工血管表面内皮细胞黏附及人工血管材料表面的接技改性等.
당인공혈관이식체내후,재료표면회흡부γ-구단백혹섬유단백원,역우사혈액중세포성분여혈소판점부우표면,혈소판-단피흡부,가이변성편평상이피격활,종이도치혈소판불가역취집이산생혈전.재대우6 mm구경인공혈관이식중,유교고적혈관통창솔,이재소구경인공혈관(<6 mm)이식중,유우저혈류량상태,역형성혈전.인차유필요대소문경인공혈관진행표면개성,증가혈액상용성,주요개성방법유개변인공혈관재료표면결구,증가인공혈관표면내피세포점부급인공혈관재료표면적접기개성등.
Vascular prosthesis can absorb y-globulin or fibrinogen when they are transplanted in vivo, accordingly the cellular components in blood, such as platelet, are easy to attach on surface and become fiat shape to be activated, which then result in an inreversible aggregation and thrombus formation. During the process of transplanting vascular prosthesis at a diameter of more than 6 mm, a high vascular patency rate can be observed, while small-diameter (< 6 mm) vascular prosthesis transplantation is under low blood flow, therefore it produces the thrombosis. It is necessary to conduct surface modification of small-diameter vascular prosthesis and to enhance hemocompatibility. The main methods of modification include the alter of surface structure of vascular prosthesis, the augmentation of endothelial cells attachment on surface of vascular prosthesis, and grafting modification of vascular prosthesis surface.