CAJ | 학술논문

癌钙调蛋白(OM)是钙结合蛋白家族中的一员,属于肌钙蛋白C超家族,它具有不同于其他钙结合蛋白的特异性钙结合(CD)区域.通过研究其结构和分布特征,发现OM在调节细胞的电活动、调控细胞内信号传导通路及细胞周期等方面发挥着重要的作用.近年来,OM在促进神经轴突再生方面的研究是目前研究的热点之一,尤其是在视神经再生的研究方面取得了一定的成绩,并有待运用于临床.OM促进视神经再生的作用为解决脊髓和脑神经的再生性难题打下了基础.对OM的概念、组织的分布、主要的作用及机制、与视神经再生的关系方面进行综述.
암개조단백(OM)시개결합단백가족중적일원,속우기개단백C초가족,타구유불동우기타개결합단백적특이성개결합(CD)구역.통과연구기결구화분포특정,발현OM재조절세포적전활동、조공세포내신호전도통로급세포주기등방면발휘착중요적작용.근년래,OM재촉진신경축돌재생방면적연구시목전연구적열점지일,우기시재시신경재생적연구방면취득료일정적성적,병유대운용우림상.OM촉진시신경재생적작용위해결척수화뇌신경적재생성난제타하료기출.대OM적개념、조직적분포、주요적작용급궤제、여시신경재생적관계방면진행종술.
Oncomodulin(OM) is a kind of Ca-bind protein(CABP),and it belongs to the tropon in C super family.It different from other CABP because of its special domain(CD domain) which could bind with Ca2+.Multiple functions of OM have been determined during the study of its construction and distribution.It plays very important role in adjusting cell electric activity,regulating cell signal conduction passageway and cell cycle.In recent years,the study on OM promoting axon regeneration is emerging,especially in the regeneration of optical nerve.It offers a basis for solving the regeneration of spinal cord and cranial nerve.The concept,construction and distribution,action mechanism and its relationship with regeneration of optical nerve were reviewed in this article.