CAJ | 학술논문

目的探讨支气管哮喘(哮喘)患者呼气冷凝液(EBC)中氮氧化物与气道炎症的关系.方法哮喘患者急性发作期30例,缓解期13例,健康对照组30例,收集其EBC,用分光光度法检测EBC中NO2-、NO3-、总NO2-/NO3-浓度.结果哮喘急性发作期EBC中NO2(1.508±0.705)μmol/L显著高于健康对照组(0.605±0.299)μmol/L,(P＜0.01);缓解期NO2-(0.622±0.253)μmol/L较急性发作期显著下降(P＜0.01).EBC中NO3-、总NO2-/NO3-的浓度在急性发作期及缓解期变化均无显著性差异(P＞0.05).结论 EBC中NO2-水平高低与哮喘病情变化有关,故可作为哮喘患者气道炎症反应的一项重要监测指标.
목적 탐토지기관효천(효천)환자호기냉응액(EBC)중담양화물여기도염증적관계.방법 효천환자급성발작기30례,완해기13례,건강대조조30례,수집기EBC,용분광광도법검측EBC중NO2-、NO3-、총NO2-/NO3-농도.결과 효천급성발작기EBC중NO2(1.508±0.705)μmol/L현저고우건강대조조(0.605±0.299)μmol/L,(P＜0.01);완해기NO2-(0.622±0.253)μmol/L교급성발작기현저하강(P＜0.01).EBC중NO3-、총NO2-/NO3-적농도재급성발작기급완해기변화균무현저성차이(P＞0.05).결론 EBC중NO2-수평고저여효천병정변화유관,고가작위효천환자기도염증반응적일항중요감측지표.
Objective To investigate the relationship between nitrogen oxides of exhaled breath condensate(EBC) and the airway inflammation in patients with asthma.Methods Thirty patients with asthma exacerbation,13asthma remission and 30 healthy controls performed EBC collection.NO2-,NO3- and total NO2-/NO3- in EBC were measured by the spectrophotometry.Results The level NO2-(1.508±0.705)μmol/L in EBC of asthma exacerbation group was significantly increased than that in control group(0.605±0.299)μmol/L (P＜0.01).NO2- in EBC showed decreased significantly in remission groud than that in exacerbation groud (P＜0.01).The levels of NO3- and total NO2-/NO3- were no significant difference in all groups.Conclusion These findings suggest that inflammation was characteristic in the airways of asthma patients.The levels of NO2 in EBC are associated with the change of asthma and may prove to be useful inmonitoring of airway inflammation in asthma.