中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2010年
18期
2460-2461,后插1
,共3页
肝肿瘤%模型,动物%兔
肝腫瘤%模型,動物%兔
간종류%모형,동물%토
Liver neoplasms%Models animal%Rabbit
目的 观察VX2兔肝癌的超声检查影像学及病理学特征.方法 采用超声引导下穿刺组织块接种法建立VX2肝癌兔模型20只,分别于接种后14 d、21 d行超声检查,并于检查后处死动物,行病理学检查.结果 20只VX2肝癌兔模型均建立成功.超声影像学表现:在肿瘤种植后14 d,20只中超声检查检出瘤灶18只,肿瘤直径8.6～11.8 mm,平均(10.15±0.67)mm;在肿瘤种植21 d时,超声检出瘤灶20只,瘤灶直径13.2～18.3 mm,平均(16.13±1. 98)mm.二维超声影像表现为圆形或类圆形的均匀低回声病灶,无包膜回声,其周边血供丰富,中央血供稀少.病理学大体检查见肿瘤呈结节状,无包膜,肿瘤切面呈灰白色,鱼肉样;光镜下癌细胞呈巢状分布,体积大,呈不规则排列,胞核大而深染,胞质量少.结论 兔VX2肝癌病灶呈结节状,光镜下癌细胞呈巢状分布,异型性明显;超声检查是一种监测肝癌模型的有效手段.
目的 觀察VX2兔肝癌的超聲檢查影像學及病理學特徵.方法 採用超聲引導下穿刺組織塊接種法建立VX2肝癌兔模型20隻,分彆于接種後14 d、21 d行超聲檢查,併于檢查後處死動物,行病理學檢查.結果 20隻VX2肝癌兔模型均建立成功.超聲影像學錶現:在腫瘤種植後14 d,20隻中超聲檢查檢齣瘤竈18隻,腫瘤直徑8.6～11.8 mm,平均(10.15±0.67)mm;在腫瘤種植21 d時,超聲檢齣瘤竈20隻,瘤竈直徑13.2～18.3 mm,平均(16.13±1. 98)mm.二維超聲影像錶現為圓形或類圓形的均勻低迴聲病竈,無包膜迴聲,其週邊血供豐富,中央血供稀少.病理學大體檢查見腫瘤呈結節狀,無包膜,腫瘤切麵呈灰白色,魚肉樣;光鏡下癌細胞呈巢狀分佈,體積大,呈不規則排列,胞覈大而深染,胞質量少.結論 兔VX2肝癌病竈呈結節狀,光鏡下癌細胞呈巢狀分佈,異型性明顯;超聲檢查是一種鑑測肝癌模型的有效手段.
목적 관찰VX2토간암적초성검사영상학급병이학특정.방법 채용초성인도하천자조직괴접충법건립VX2간암토모형20지,분별우접충후14 d、21 d행초성검사,병우검사후처사동물,행병이학검사.결과 20지VX2간암토모형균건립성공.초성영상학표현:재종류충식후14 d,20지중초성검사검출류조18지,종류직경8.6～11.8 mm,평균(10.15±0.67)mm;재종류충식21 d시,초성검출류조20지,류조직경13.2～18.3 mm,평균(16.13±1. 98)mm.이유초성영상표현위원형혹류원형적균균저회성병조,무포막회성,기주변혈공봉부,중앙혈공희소.병이학대체검사견종류정결절상,무포막,종류절면정회백색,어육양;광경하암세포정소상분포,체적대,정불규칙배렬,포핵대이심염,포질량소.결론 토VX2간암병조정결절상,광경하암세포정소상분포,이형성명현;초성검사시일충감측간암모형적유효수단.
Objective To study the pathological characteristic of VX2 hepatic tumor in rabbit and the value of ultrasound in detecting this tumor mode. Methods To establish a model of Rabbit Liver VX2 Tumor with ultrasound- guided implantation of constitution mass and ultrasounds scanning was performed at fourteen days and twentyone days after implantation. After that, all the rabbits were executed and pathological examination was performed. Results Twenty models of Rabbit Liver VX2 Tumor were successfully established. The fourteen days after implantation,18 rabbits were found tumor,tumor diameter 8. 6 ～ 11.8 mm, average diameter ( 10. 15 ± 0. 67) mm; The twenty one days after implantation,20 rabbits were found tumor, tumor diameter 13.2 ～ 18.3 mm, average diameter( 16. 13 ±1.98)mm. Ultrasound showed that the tumor in the rabbit liver was a single spherical or sphere-alike hypoechoic nudes,and there were higher blood flow signals around the nedus. In pathological examination,the tumors were exserted to the liver surface,the cross sections of the tumor were gray,the cells of the tumors were bigger than the normal liver cells,arranged into nests with fibrous tissue. Conclusion In pathological examination, the heteromorphism of VX2 tumor cell was conspicuous. The growth of VX2 hepatoma could be monitored by ultrasound effectively.
