CAJ | 학술논문

目的探讨颅骨原发性非霍奇金淋巴瘤的临床分类、特点及诊治原则,以提高对该疾病认识.方法总结国内此类疾病的个案报道,对本科经治且病理证实的3例患者进行回顾性研究.结果 2例出现眼球外突,1例发现额顶部无痛性肿物;3例均行手术治疗;病理均符合原发非霍奇金淋巴瘤诊断;术后分别行CHOP或MTX方案化疗,随访期内2例生存,1例死亡.结论颅骨原发性非霍奇金淋巴罕见,依发病部位可分为颅盖组和颅底组两型,其在发病年龄和首发症状上存在差异,影像学表现具有一定特征性,应采取手术结合放、化疗的综合治疗,大剂量甲氨蝶呤化疗效果良好.
목적 탐토로골원발성비곽기금림파류적림상분류、특점급진치원칙,이제고대해질병인식.방법 총결국내차류질병적개안보도,대본과경치차병리증실적3례환자진행회고성연구.결과 2례출현안구외돌,1례발현액정부무통성종물;3례균행수술치료;병리균부합원발비곽기금림파류진단;술후분별행CHOP혹MTX방안화료,수방기내2례생존,1례사망.결론 로골원발성비곽기금림파한견,의발병부위가분위로개조화로저조량형,기재발병년령화수발증상상존재차이,영상학표현구유일정특정성,응채취수술결합방、화료적종합치료,대제량갑안접령화료효과량호.
Objective To investigate the clinical characteristics of primary non-Hodgkin's lymphoma of skull bone(PLSB).Method Three cases of primary non-Hodgkin's lymphoma of skull bone were treated in our hospital between Mar.2008 and Aug.2009.The clinical characteristics and outcomes of them were reviewed.Results 2 patients were admitted for exophthalmos,and 1 patient for scalp mass.The preoperative imagings varied according to different patients.All of them were misdiagnosised before operation.They received biopsy or subtotal resection of tumors,and followed by chemotherapy.All patients were followed-up,and two of them were stable,and 1 patient dead of lymphocytic leukemia.Conclusions PLSBs are rare lesions contrast to primary central nervous system lymphoma.PLSBs can be divided into 2 groups according to the location of the lesions.Symptoms and admission age are different in these two series.Misdiagnosis is more frequent for complicated neuroimagings.Resection combined with chemotherapy and radiotherapy are recommended for its treatment.High dose of methotrexate is verified to be effective.This lesion has an uncertain prognosis.