CAJ | 학술논문

目的分析供肾穿刺活榆在亲属活体肾移植中对供肾质量的诊断价值及边缘供肾对亲属活体肾移植受者早期预后的影响.方法 2004年2月至2008年7月142例亲属活体肾移植患者,按照供体年龄和供肾情况分为边缘供者组(51例)和非边缘供者组(91例).并对49例亲属活体供肾行细针穿刺活检术.分析2组受者的术后血肌酐(Scr)变化、Scr最低值、所需时间、术后并发症发生率.结果 49例亲属活体供肾中13例发生病理改变.边缘供者组受者Scr在术后4周、12周、6月及最低Scr水平均高于非边缘供者组(均P＜0.05),而术后12个月、24个月、36个月Scr和Scr恢复至最低水平所需时间差异无统计学意义(均P＞0.05).边缘供肾受者术后并发症发生率与非边缘供肾受者差异无统计学意义.结论边缘供肾受者的早期临床疗效是理想的,但术后血肌酐基线较非边缘供肾患者高,应严格控制其纳入标准.供肾穿刺活检有利于发现常规无创检查难以发现的潜在肾脏疾病,对供受者具有重要诊断和治疗价值.
목적 분석공신천자활유재친속활체신이식중대공신질량적진단개치급변연공신대친속활체신이식수자조기예후적영향.방법 2004년2월지2008년7월142례친속활체신이식환자,안조공체년령화공신정황분위변연공자조(51례)화비변연공자조(91례).병대49례친속활체공신행세침천자활검술.분석2조수자적술후혈기항(Scr)변화、Scr최저치、소수시간、술후병발증발생솔.결과 49례친속활체공신중13례발생병리개변.변연공자조수자Scr재술후4주、12주、6월급최저Scr수평균고우비변연공자조(균P＜0.05),이술후12개월、24개월、36개월Scr화Scr회복지최저수평소수시간차이무통계학의의(균P＞0.05).변연공신수자술후병발증발생솔여비변연공신수자차이무통계학의의.결론 변연공신수자적조기림상료효시이상적,단술후혈기항기선교비변연공신환자고,응엄격공제기납입표준.공신천자활검유리우발현상규무창검사난이발현적잠재신장질병,대공수자구유중요진단화치료개치.
Objective To analyze diagnostic value of renal biopsy in living-related kidney transplantation and the influence of kidneys from marginal donors on the early prognosis of recipients. Methods According to donors age and risks of donors, 142 living-related kidney transplant recipients from February 2004 to July 2008 were divided into marginal donor group (51 cases) and non-marginal donor group (91 cases). Renal biopsy was performed on 49 kidneys Postsurgical serum creatinine (Scr), the lowest Scr and post-transplant complications were analyzed between the two groups. Results Pathological changes were detected in 13 cases. The Scr at 4 weeks, 12 weeks, 6 months post-transplant and the lowest level of Scr in marginal donor group were higher than those in non-marginal donor group (all P<0.05). There were no significant differences of Scr levels at 12 months, 24 months, 36 months post-transplant, the time required to return to the lowest Scr, and post-transplant complications between two groups (all P>0.05). Conclusions The early clinical efficacy of the marginal donor is ideal, but the baseline of Scr of recipients is higher than that of recipients with kidneys from non-marginal donors. Renal biopsy has an important diagnostic and therapeutic value for both donors and recipients.