CAJ | 학술논문

目的探讨立体定向穿刺活检加内放疗联合γ-刀治疗囊性胶质瘤的有效性和安全性.方法对24例脑深部及功能区囊性脑胶质瘤行CT导向立体定向穿刺活检,抽吸囊液并置人同位素32P内放疗后再对胶质瘤实体部分(包括囊壁)行γ-刀治疗,其中13例置入Ommaya管.结果术后24例临床症状均有好转或改善.术后2～3个月行影像学复查,显效17例,有效5例,无效1例,恶化1例,有效率为91.7%(22/24).术后随访6～36个月,术后6、12、24、36个月生存率分别为95.8%(23/24)、83.3%(20/24)、63.2%(12/19)、46.2%(6/13).无手术严重并发症发生.结论利用立体定向术加内放疗联合γ-刀治疗脑深部及功能区囊性胶质瘤,具有微创、安全、并发症少、有明显的近期效果和有效的肿瘤控制率等优点.
목적 탐토입체정향천자활검가내방료연합γ-도치료낭성효질류적유효성화안전성.방법 대24례뇌심부급공능구낭성뇌효질류행CT도향입체정향천자활검,추흡낭액병치인동위소32P내방료후재대효질류실체부분(포괄낭벽)행γ-도치료,기중13례치입Ommaya관.결과 술후24례림상증상균유호전혹개선.술후2～3개월행영상학복사,현효17례,유효5례,무효1례,악화1례,유효솔위91.7%(22/24).술후수방6～36개월,술후6、12、24、36개월생존솔분별위95.8%(23/24)、83.3%(20/24)、63.2%(12/19)、46.2%(6/13).무수술엄중병발증발생.결론 이용입체정향술가내방료연합γ-도치료뇌심부급공능구낭성효질류,구유미창、안전、병발증소、유명현적근기효과화유효적종류공제솔등우점.
Objective To explore the stereotactic biopsy of cystic gliomas.the curative effects of intracystic radiothempy combined with gamma knife surgery on them，and their safety.Methods The clinical data of 24 patients with cystic gliomas，who underwent stereotaetic biopsy，intracystic radiotherapy with 32P and then gamma knife radiosurgery.were analyzed retrospectively.The gamma knife mdiosurgery was directed against the solid part of the cystic gliomas.Ommaya reservoirs were placed under the scalps in 13 patients.Results All the patients were impmved in the clinical symptoms after the treatment.The imaging examination from 2 to 3 months after the treatment showed that the tumors decreased in volume by more than 50%in 17 cases， and by from 25%to 50%in 5, and the volume of the tumor was insignificantly unchanged in 1 and enhanced in 1.During following up from 6 to 36 months(mean，23.5 month)，The survival rates in 0.5，1，2 and 3 years were 95.8%(23/24)，83.3%(20/24)，63.2%(12/19)and 46.2%(6/13) respectively.No severe postoperative complication occurled in all the patients.Conclusions The stereotactic biopsy and intraeystic radiotherapy combined with Gamma knife radiosurgery are a safe and effective method to treat cystic gliomas.