CAJ | 학술논문

小鼠口服不同剂量断奶安14～18 h后分别经腹腔和静脉感染大肠埃希氏杆菌O_1和O_2,结果断奶安组腹腔感染大肠埃希氏杆菌O_1的小鼠存活率达60%(对照组存活率10%),腹腔感染大肠埃希氏杆菌O_2的小鼠的存活率为50%(对照组全部死亡);静脉感染大肠埃希氏杆菌O_2的小鼠存活率达90%(对照组存活率为30%),静脉感染大肠埃希氏杆菌O_2的小鼠存活率达60%(对照组存活率为10%).小鼠经腹腔分别感染金黄色葡萄球菌(2×10~7CFU/20g)和大肠埃希氏杆菌O_1(5×10~7CFU/20 g)后,口服断奶安进行治疗试验,结果金黄色葡萄球菌感染组灌服断奶安100mg/kg、1000mg/kg、2000mg/kg、3000mg/kg和蒸馏水后,存活率分别为40%、70%、70%、80%和0;大肠埃希氏杆菌感染组分别灌服1000mg/kg、1500mg/kg,2000mg/kg断奶安和蒸馏水后,存活率分别为40%、60%、50%和10%.表明,断奶安具有一定的免疫增强作用.
소서구복불동제량단내안14～18 h후분별경복강화정맥감염대장애희씨간균O_1화O_2,결과단내안조복강감염대장애희씨간균O_1적소서존활솔체60%(대조조존활솔10%),복강감염대장애희씨간균O_2적소서적존활솔위50%(대조조전부사망);정맥감염대장애희씨간균O_2적소서존활솔체90%(대조조존활솔위30%),정맥감염대장애희씨간균O_2적소서존활솔체60%(대조조존활솔위10%).소서경복강분별감염금황색포도구균(2×10~7CFU/20g)화대장애희씨간균O_1(5×10~7CFU/20 g)후,구복단내안진행치료시험,결과금황색포도구균감염조관복단내안100mg/kg、1000mg/kg、2000mg/kg、3000mg/kg화증류수후,존활솔분별위40%、70%、70%、80%화0;대장애희씨간균감염조분별관복1000mg/kg、1500mg/kg,2000mg/kg단내안화증류수후,존활솔분별위40%、60%、50%화10%.표명,단내안구유일정적면역증강작용.
Mice were infected with E. coli O_1 and O_2 respectively by both intravenous injection and intraperitoneal injection after orally administrated duannaian 14～18h. The survival rates of duannaian group with intraperitoneal injection were 60% (control group was 10%) and 50% (control group was zero) respectively. The survival rates of duannaian group with intravenous injection were 90% (control group was 30%) and 60%(control group was 10%) respectively. Therapeutic effects of duannaian were investigated in mice which were orally administrated duannaian after abdominal infected with Staphyloccocus aureus and E. coli O_1 respectively. The result showed that the survival rates of duannaian group 100 mg/kg, 1000 mg/kg, 2 000 mg/kg, 3 000 mg/kg and distilled water group were 40%, 70%, 700%, 80% and 0 respectively after infected with Staphyloccocus aureus. As for the groups in which mice were infected with E. coli O_1, the result indicated that the survival rates of duannaian group 1000mg/kg, 1500mg/kg, 2000mg/kg and distilled water group were 40%, 60%, 50% and 10% respectively.Therefore, duannaian can enhance immune function.