CAJ | 학술논문

阿尔茨海默病患者脑脊液中葡萄糖、真胰岛素水平与载脂蛋白E基因的关系
아이자해묵병환자뇌척액중포도당、진이도소수평여재지단백E기인적관계
Relation between the levels of glucose and true insulin in cerebrospinal fluid and apolipoprotein E genotype in patients with Alzheimer's disease

万方数据

中国老年学杂志中國老年學雜誌 중국노년학잡지
CHINESE JOURNAL OF GERONTOLOGY
2010年 3期 291-293 ,共3页

刘卫刚%刘蓉辉%田瑞振%齐亚超%李娜%刘桂芳%赵大卫%冯亚青%哈志远

류위강%류용휘%전서진%제아초%리나%류계방%조대위%풍아청%합지원

阿尔茨海默病%脑脊液%葡萄糖%真胰岛素%载脂蛋白E基因阿爾茨海默病%腦脊液%葡萄糖%真胰島素%載脂蛋白E基因
아이자해묵병%뇌척액%포도당%진이도소%재지단백E기인
Alzheimer's disease%Cerebrospinal fluid%Glucose%True insulin%Apolipoprotein E gene

目的检测阿尔茨海默病(AD)患者脑脊液中葡萄糖、真胰岛素水平,探讨AD患者脑脊液中胰岛素异常及与载脂蛋白E(ApoE)基因的关系.方法随机选择35例对照组、48例AD患者,留取脑脊液检验其葡萄糖、真胰岛素水平,将AD按轻、中重度和不同ApoE基因型分组后与相应的对照组进行比较.结果 AD患者各组脑脊液中葡萄糖与相应对照组比较,无显著性差异(P> 0.05);轻度AD组脑脊液真胰岛素较对照组无显著性差异(P> 0.05),中重度AD组真胰岛素较对照组降低,有显著性差异(P< 0.05);无ApoEε4 AD组较对照组真胰岛素降低,有显著性差异(P< 0.05).结论 AD患者脑脊液中胰岛素水平降低,与疾病的严重程度和ApoEε4基因型相关.
목적 검측아이자해묵병(AD)환자뇌척액중포도당、진이도소수평,탐토AD환자뇌척액중이도소이상급여재지단백E(ApoE)기인적관계.방법 수궤선택35례대조조、48례AD환자,류취뇌척액검험기포도당、진이도소수평,장AD안경、중중도화불동ApoE기인형분조후여상응적대조조진행비교.결과 AD환자각조뇌척액중포도당여상응대조조비교,무현저성차이(P> 0.05);경도AD조뇌척액진이도소교대조조무현저성차이(P> 0.05),중중도AD조진이도소교대조조강저,유현저성차이(P< 0.05);무ApoEε4 AD조교대조조진이도소강저,유현저성차이(P< 0.05).결론 AD환자뇌척액중이도소수평강저,여질병적엄중정도화ApoEε4기인형상관.
Objective To detect the levels of glucose and true insulin in cerebrospinal fluid (CSF) and apolipoprotein E genotype in patients with Alzheimer's disease (AD) and explore whether the insulin levels are related to the severity of dementia and apolipoprotein E (ApoE) or not. Methods The levels of glucose and true insulin in CSF and apoE genotype in 35 healthy age-matched adults and 48 patients with AD were measured and analyzed. Results There was no difference between AD group and its control group in the levels of glucose in CSF (P> 0.05). There was no difference between mild AD group and its control group in the levels of true insulin (P> 0.05). True insulin in moderate/severe AD group was significantly lower than that of its control group (P< 0.05). True insulin in the AD/no-apoEε4 genotype group was significantly lower than that of its control group (P< 0.05). Conclusions The lower insulin level in AD patients is related to severity of the disease and apoEε4 genotype.