CAJ | 학술논문

泌乳素诱导蛋白(PIP)被认为是乳腺癌较特异性的标记物,检测其在乳腺癌组织、转移淋巴结及外周血中的表达对早期发现乳腺癌微转移具有提示意义.免疫组织化学、逆转录聚合酶链反应等技术在检测PIP表达时具有敏感性,现已广泛应用于临床与基础研究.联合检测乳腺珠蛋白、细胞角蛋白(CK)19等标记物可有效提高微转移的检出率.
비유소유도단백(PIP)피인위시유선암교특이성적표기물,검측기재유선암조직、전이림파결급외주혈중적표체대조기발현유선암미전이구유제시의의.면역조직화학、역전록취합매련반응등기술재검측PIP표체시구유민감성,현이엄범응용우림상여기출연구.연합검측유선주단백、세포각단백(CK)19등표기물가유효제고미전이적검출솔.
Prolactin-inducible protein(PIP)is regarded as a kind of specific tumor marker,and detecting the expression of PIP from breast cancer tissues,metastatic lymph nodes and peripheral blood can find breast cancer micro-metastasis effectively.Some technologies such as immunohistochemistry,reverse transcription polymerase chain reaction and so on can detect PIP sensitivily.Recently,these technologies have been used in some clinical and basic studies.Detection rate of breast cancer micro-metastasis is improved effectively when PIP is combined with other tumor makers,especially mammag-lobin and cytokeratin 19.